A model platform for studies of the microbiome on vascular injury response

      The physiologic process of the vascular response to injury is enormously variable. When the response includes substantial intimal proliferation, it poses the severe practical problem of flow-limiting obstruction as a consequence of manipulation of vessels during surgical and percutaneous interventional vascular procedures. Finding solutions to this problem requires the development of a thorough understanding of the mechanisms of the injury response that result in pathologic intimal thickening. This has proved to be challenging, and our current clinical methods for managing neointimal hyperplasia (NIH) are crude at best.
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        Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
        J Vasc Surg. 2020; 71: 1378-1389

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      • Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty
        Journal of Vascular SurgeryVol. 71Issue 4
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          Neointimal hyperplasia is a major contributor to restenosis after arterial interventions, but the genetic and environmental mechanisms underlying the variable propensity for neointimal hyperplasia between individuals, including the role of commensal microbiota, are not well understood. We sought to characterize how shifting the microbiome using cage sharing and bedding mixing between rats with differing restenosis phenotypes after carotid artery balloon angioplasty could alter arterial remodeling.
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