Journal of Vascular Surgery
Volume 30, Issue 3 , Pages 569-572 , September 1999

Nitric oxide and the vascular surgeon

Received 29 April 1999 ,Accepted 4 May 1999.

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    Metabolic pathway of nitric oxide (NO) in blood vessel wall. Endothelial cells secrete NO in response to variety of external stimuli. NO is released during conversion of L -arginine to citrulline with

    Metabolic pathway of nitric oxide (NO) in blood vessel wall. Endothelial cells secrete NO in response to variety of external stimuli. NO is released during conversion of L -arginine to citrulline with NO synthase (NOS) . This enzyme is dependent on cofactors flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) , tetrahydrobiopterin (BH 4 ) calmodulin, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) . After release from endothelial cell, NO diffuses into extracellular milieu where it can react with smooth muscle cells or undergo variety of other reactions. cGMP, Cyclic guanosine monophosphate; Ach, acetycholine; ADP, adenosine diphosphate.

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    Beneficial effects of nitric oxide (NO) on blood vessel wall.

    Beneficial effects of nitric oxide (NO) on blood vessel wall.

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    Causes of endothelial dysfunction and their relationship to clinical events.

    Causes of endothelial dysfunction and their relationship to clinical events.

☆ From the Division of Vascular Surgery, Department of Surgery, Medical College of Virginia Campus at Virginia Commonwealth University.

☆☆ Reprint requests: Dr Raymond G. Makhoul, Medical College of Virginia, Department of Surgery, Division of Vascular Surgery, PO Box 980108, Richmond, VA 23298.

★ J Vasc Surg 1999;30:569-72.

★★ 0741-5214/99/$8.00 + 0  24/9/100108

PII: S0741-5214(99)70087-X

Journal of Vascular Surgery
Volume 30, Issue 3 , Pages 569-572 , September 1999

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