Journal of Vascular Surgery
Volume 52, Issue 3 , Pages 624-631 , September 2010

Leg strength predicts mortality in men but not in women with peripheral arterial disease

  • Nimarta Singh, BA

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Ill
    • ,
  • Kiang Liu, PhD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Ill
    • ,
  • Lu Tian, ScD

      Affiliations

    • Stanford University, Palos Altos, Calif
    • ,
  • Michael H. Criqui, MD, PhD

      Affiliations

    • University of California at San Diego, San Diego, Calif
    • ,
  • Jack M. Guralnik, MD, PhD

      Affiliations

    • National Institute on Aging, Bethesda, Md
    • ,
  • Luigi Ferrucci, MD, PhD

      Affiliations

    • National Institute on Aging, Bethesda, Md
    • ,
  • Yihua Liao, MS

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Ill
    • ,
  • Mary M. McDermott, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Ill
    • Corresponding Author InformationReprint requests: Dr Mary M. McDermott, 750 N. Lake Shore Dr., 10th Floor, Chicago, IL 60611

Received 22 February 2010 ,Accepted 26 March 2010.

References 

  1. McDermott MM, Greenland P, Liu K, Guralnik JM, Celic L, Criqui MH, et al. The ankle brachial index is associated with leg function and physical activity: the walking and leg circulation study. Ann Intern Med. 2002;136:873–883
  2. Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: A meta-analysis. JAMA. 2008;300:197–208
  3. McDermott MM, Hoff F, Ferrucci L, Pearce WH, Guralnik JM, Tian L, et al. Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease. J Am Geriatr Soc. 2007;55:400–406
  4. McDermott MM, Criqui MH, Greenland P, Guralnik JM, Liu K, Pearce L, et al. Leg strength in peripheral arterial disease: associations with disease severity and lower extremity performance. J Vasc Surg. 2004;39:523–530
  5. McDermott MM, Ferrucci L, Guralnik JM, Tian L, Liu K, Hoff F, et al. Pathophysiologic changes in calf muscle predict mobility loss at two-year follow-up in men and women with peripheral arterial disease. Circulation. 2009;120:1048–1055
  6. Herman SD, Liu K, Tian L, Guralnik JM, Ferrucci L, Criqui MH, et al. Baseline lower extremity strength and subsequent decline in functional performance at 6-year follow-up in persons with lower extremity peripheral arterial disease. J Am Geriatr Soc. 2009;57:2246–2252
  7. McDermott MM, Criqui MH, Guralnik JM, Greenland P, Martin GJ, Pearce W. Lower ankle brachial index, as calculated by averaging the dorsalis pedis and posterior tibial arterial pressures, and associations with functioning in peripheral arterial disease. J Vasc Surg. 2000;32:1164–1171
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  9. In:  Guralnik JM,  Fried LP,  Simonsick EM,  Kasper JD,  Lafferty ME editor. The Women's Health and Aging Study: health and social characteristics of older women with disability. Bethesda, MD: National Institute on Aging; 1995;NIH publication 95-4009, Appendix E
  10. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis (Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association). Arthritis Rheum. 1986;29:1039–1049
  11. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Arthritis Rheum. 1986;29:1039–1049
  12. Lee IM, Paffenbarger RS, Hsieh CC. Time trends in physical activity among college alumni, 1962-1988. Am J Epidemiol. 1992;135:912–925
  13. Garg PK, Tian L, Criqui MH, Liu K, Ferrucci L, Guralnik JM, et al. Physical activity during daily life and mortality in patients with peripheral arterial disease. Circulation. 2006;114:242–248
  14. Lu K, Tsiatis AA. Multiple imputation methods for estimating regression coefficients in the competing risks model with missing cause of failure. Biometrics. 2001;57:1191–1197
  15. Regensteiner JG, Wolfel EE, Brass EP, Carry MR, Ringel SP, Hargarten ME, et al. Chronic changes in skeletal muscle histology and function in peripheral arterial disease. Circulation. 1993;87:413–421
  16. McDermott MM, Tian L, Liu K, Guralnik JM, Ferrucci L, Tan J, et al. Prognostic value of functional performance for mortality in patients with peripheral arterial disease. J Am Coll Cardiol. 2008;51:1482–1489
  17. McDermott MM, Ades P, Guralnik JM, Dyer A, Ferrucci L, Liu K, et al. Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial. JAMA. 2009;301:165–174

 Supported by the National Heart Lung and Blood Institute, National Institutes of Health (R01-HL58099, R01-HL64739, R01-HL071223, and R01-HL076298) and the National Center for Research Resources, National Institutes of Health (#RR-00048) and by the Intramural Research Program, National Institutes on Aging, National Institutes of Health.

 Competition of interest: none.

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(10)00889-X

doi: 10.1016/j.jvs.2010.03.066

Journal of Vascular Surgery
Volume 52, Issue 3 , Pages 624-631 , September 2010

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