Journal of Vascular Surgery
Volume 52, Issue 1 , Pages 1-4 , July 2010

Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms

  • Michael J. Sweeting

      Affiliations

    • MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    • ,
  • Simon G. Thompson

      Affiliations

    • MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    • ,
  • Louise C. Brown

      Affiliations

    • Vascular Surgery Research Group, Imperial College at Charing Cross, London, United Kingdom
    • ,
  • Roger M. Greenhalgh

      Affiliations

    • Vascular Surgery Research Group, Imperial College at Charing Cross, London, United Kingdom
    • ,
  • Janet T. Powell

      Affiliations

    • Vascular Surgery Research Group, Imperial College at Charing Cross, London, United Kingdom
    • Corresponding Author InformationReprint requests: Janet T. Powell, Vascular Surgery Research Group, Imperial College at Charing Cross, St Dunstan's Road, London, W6 8RP, UK

Received 10 December 2009 ,Accepted 23 February 2010.

References 

  1. NHS Abdominal aortic aneurysm screening program. http://aaa.screening.nhs.uk/Accessed October 2009
  2. Guessous I, Periard D, Lorenzetti D, Cornuz J, Ghali WA. The effect of pharmacotherapy for decreasing the expansion rate of abdominal aortic aneurysms: a systematic review and meta-analysis. PLoS ONE. 2008;3:e1895
  3. Hackam DG, Thiruchelvam D, Redelmeier DA. Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet. 2006;368:659–665
  4. NIHR Health technology assessment program. www.hta.ac.uk/funding/briefsarchive/08_109cb.pdfAccessed March 2008
  5. UK Small Aneurysm Trial Participants. Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet. 1998;352:1649–1655
  6. UK Small Aneurysm Trial Participants. Long-term outcomes of immediate repair compared with surveillance for small abdominal aortic aneurysm. New Engl J Med. 2002;346:1445–1452
  7. Brady AR, Thompson SG, Fowkes FG, Greenhalgh RM, Powell JT. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation. 2004;110:16–21
  8. Vardulaki KA, Prevost TC, Walker NM, Day NE, Wilmink ABM, Quick CRG, et al. Growth rates and risk of rupture of abdominal aortic aneurysms. Br J Surg. 1998;85:1674–1680
  9. Journal of the Royal Statistical Society: Series A Statistics in Society (submitted). www.mrc-bsu.cam.ac.uk/Publications/Preprints/AAA_predictions.pdfAccessed April 2009
  10. Royston P. Multiple imputation of missing values: further update of ice, with an emphasis on categorical variables. Stata J. 2009;9:466–477
  11. Lu H, Ratieri DL, Cassis LA, Daugherty A. The role of the renin-angiotensin system in aortic aneurysmal diseases. Curr Hypertens Rep. 2008;10:99–106
  12. Ferguson CD, Clancy P, Bourke B, Walker PJ, Dear A, Buckenham T, et al. Association of statin prescription with small abdominal aortic aneurysm progression. Am Heart J. 2010;159:307–313
  13. Vega de Ceniga M, Gomez R, Estallo L, Rodrigues MBaquer, Barba A. Growth rate and associated factors in small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2006;31:231–236
  14. Hemels MEH, Bonari L, Han D, Traverso ML, Einarson TR. HOPE study impact on ACE Inhibitors Use. Ann Pharmacother. 2003;37:640–645
  15. Lederle FA, Taylor BC. ACE inhibitors and aortic rupture. Lancet. 2006;368:1571

 The UK Small Aneurysm Trial and Study were supported by the Medical Research Council and the British Heart Foundation.

 Competition of interest: Mr Sweeting is employed by the UK Medical Research Council (NIHR HTA grant 08/30/02).

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(10)00649-X

doi: 10.1016/j.jvs.2010.02.264

Journal of Vascular Surgery
Volume 52, Issue 1 , Pages 1-4 , July 2010

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