Journal of Vascular Surgery
Volume 52, Issue 1 , Pages 85-90 , July 2010

Biomarkers in peripheral arterial disease patients and near- and longer-term mortality

  • Michael H. Criqui, MD, MPH

      Affiliations

    • University of California San Diego School of Medicine, La Jolla, Calif
    • Corresponding Author InformationReprint requests: Michael H. Criqui, MD, MPH, University of California, San Diego, Department of Family and Preventive Medicine, 9500 Gilman Dr. MC:0607, La Jolla, CA 92093-0607
    • ,
  • Lindsey A. Ho, MPH

      Affiliations

    • University of California San Diego School of Medicine, La Jolla, Calif
    • School of Public Health, University of North Carolina, Chapel Hill, NC
    • ,
  • Julie O. Denenberg, MA

      Affiliations

    • University of California San Diego School of Medicine, La Jolla, Calif
    • ,
  • Paul M. Ridker, MD, MPH

      Affiliations

    • School of Public Health, Harvard University, Boston, Mass
    • ,
  • Christina L. Wassel, PhD

      Affiliations

    • University of California San Diego School of Medicine, La Jolla, Calif
    • ,
  • Mary M. McDermott, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Ill

Received 6 November 2009 ,Accepted 4 February 2010.

References 

  1. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387–1397
  2. Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005;294:326–333
  3. Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG. Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study. Circulation. 2007;115:2119–2127
  4. Ridker PM. High sensitive C-reactive protein as a predictor of all-cause mortality: Implications for research and patient care. Clin Chem. 2008;54:234–237
  5. Zethelius B, Berglund L, Sundström J, Ingelsson E, Basu S, Larsson A, et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med. 2008;358:2107–2116
  6. Tracy R, Lemaitre R, Psaty B, Ives G, Evans RW, Cushman M, et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Arterioscler Thromb Vasc Biol. 1997;17:1121–1127
  7. Cushman M, Lemaitre RN, Kuller LH, Psaty BM, Macy EM, Sharrett AR, et al. Fibrinolytic activation markers predict myocardial infarction in the elderly (The Cardiovascular Health Study). Arterioscler Thromb Vasc Biol. 1999;19:493–498
  8. Pirro M, Bergeron J, Dagenais GR, Bernard P, Cantin B, Despres J, et al. Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men. Arch Intern Med. 2001;161:2474–2480
  9. Sakkinen P, Abbott RD, Curb JD, Rodriguez BL, Yano K, Tracy RP. C-reactive protein and myocardial infarction. J Clinical Epidemiol. 2002;55:445–451
  10. Jenny NS, Yanez ND, Psaty BM, Kuller LH, Hirsch CH, Tracy RP. Inflammation biomarkers and near-term death in older men. Am J Epidemiol. 2007;165:684–695
  11. Vidula H, Tian L, Liu K, Criqui MH, Ferrucci L, Pearce WH, et al. Biomarkers of inflammation and thrombosis as predictors of near-term mortality in patients with peripheral arterial disease: a cohort study. Ann Int Med. 2008;148:85–93
  12. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ, et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326:381–386
  13. Bird CE, Criqui MH, Fronek A, Denenberg JO, Klauber MR, Langer RD. Quantitative and qualitative progression of peripheral arterial disease by non-invasive testing. Vasc Med. 1999;4:15–21
  14. Shadman R, Allison MA, Criqui MH. Glomerular filtration rate and N-terminal pro-brain natriuretic peptide as predictors of cardiovascular mortality in vascular patients. J Am Coll Card. 2007;49:2172–2181
  15. Allison MA, Denenberg JO, Nelson JJ, Natarajan L, Criqui MH. The association between lipoprotein-associated phospholipase A2 and cardiovascular disease and total mortality in vascular medicine patients. J Vasc Surg. 2007;46:500–506
  16. Shadman R, Criqui MH, Bundens WP, Fronek A, Denenberg JO, Gamst AC, et al. Subclavian artery stenosis: prevalence, risk factors, and association with cardiovascular disease. J Am Coll Cardiol. 2004;44:618–623
  17. Grambsch P, Therneau T. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81:515–526
  18. Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med. 2006;355:2631–2639
  19. Pencina MJ, D'Agostino RB, D'Agostino RB, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27:157–172
  20. SAS 9.1 for Windows, Copyright 2002-2003 by SAS Institute Inc., Cary, NC, USA.
  21. Ware JH. The limitations of risk factors as prognostic tools. N Engl J Med. 2006;355:2615–2617
  22. Cook NR, Buring JE, Ridker PM. The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med. 2006;145:21–29
  23. Cook NR. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation. 2007;115:928–935
  24. Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA. 2007;297:611–619
  25. Pearte CA, Furberg CD, O'Meara ES, Psaty BM, Kuller L, Powe NR, et al. Characteristics and baseline clinical predictors of future fatal versus nonfatal coronary heart disease events in older adults: the Cardiovascular Health Study. Circulation. 2006;113:2177–2185
  26. Elliot P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009;302:37–48

 Supported by National Institutes of Health grant HL42973., NIH-NCRR General Clinical Research Center Program Grant M01 RR00827, American Heart Association Grant-in-Aid No. 0050002N, and a small grant from Glaxo Smith Kline.

 Dr Ridker is listed as a coinventor on patents held by the Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease.

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(10)00256-9

doi: 10.1016/j.jvs.2010.02.004

Journal of Vascular Surgery
Volume 52, Issue 1 , Pages 85-90 , July 2010

Article Tools

* Image Usage & Resolution