Journal of Vascular Surgery
Volume 52, Issue 2 , Pages 512-515, August 2010

Thrombolysis for acute arterial occlusion

  • Jos C. van den Berg, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Jos C. van den Berg, MD, PhD, Service of Interventional Radiology, Ospedale Regionale di Lugano, sede Civico, Via Tesserete 46, 6903 Lugano, Switzerland

Service of Interventional Radiology, Ospedale Regionale di Lugano, sede Civico, Lugano, Switzerland

Received 4 October 2009; accepted 25 January 2010. published online 30 April 2010.

Jan D. Blankensteijn, MD, PhD, Section Editor

Introduction

Acute leg ischemia is one of the most challenging and dangerous conditions in vascular surgical practice and carries a high risk of amputation and death when left untreated. This article provides an overview of the currently held opinions on the role of catheter-based thrombolytic therapy in patients with acute leg ischemia.

Methods

A systematic review of literature from 1980 to 2009 was performed. The literature analyzed included randomized trials, large single-center case series, and review articles.

Results

Three large randomized trials and 14 review articles were identified. Pharmacologic aspects and the results of thrombolytic therapy, as well as indications, contraindications, and complications are described.

Conclusions

Catheter-directed thrombolysis can be considered a complementary and not a competing technology with surgical or percutaneous revascularization, with an acceptably low complication rate.

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 Competition of interest: none.

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(10)00242-9

doi:10.1016/j.jvs.2010.01.080

Journal of Vascular Surgery
Volume 52, Issue 2 , Pages 512-515, August 2010

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