Journal of Vascular Surgery
Volume 51, Issue 2 , Pages 372-378.e1 , February 2010

Analysis of gender-related differences in lower extremity peripheral arterial disease

Presented at the Thirty-fourth Annual Spring Peripheral Vascular Surgical Society Meeting, Denver, Colo, June 11-14, 2009.

  • Natalia Egorova, PhD, MPH

      Affiliations

    • Department of Health Evidence and Policy, Mount Sinai Medical Center, New York, NY
  • ,
  • Ageliki G. Vouyouka, MD

      Affiliations

    • Division of Vascular Surgery, Mount Sinai Medical Center, New York, NY
    • Corresponding Author InformationReprint requests: Ageliki G. Vouyouka, MD, FACS, Division of Vascular Surgery, Mount Sinai Medical Center/School of Medicine, 5 E 98th St, Box 1273, New York, NY 10029
  • ,
  • Jacquelyn Quin, MD, MPH

      Affiliations

    • Surgical Services, Roxbury VAMC, Boston, Mass
  • ,
  • Stephanie Guillerme, MS

      Affiliations

    • Department of Health Evidence and Policy, Mount Sinai Medical Center, New York, NY
  • ,
  • Alan Moskowitz, MD

      Affiliations

    • Department of Health Evidence and Policy, Mount Sinai Medical Center, New York, NY
  • ,
  • Michael Marin, MD

      Affiliations

    • Division of Vascular Surgery, Mount Sinai Medical Center, New York, NY
  • ,
  • Peter L. Faries, MD

      Affiliations

    • Division of Vascular Surgery, Mount Sinai Medical Center, New York, NY

Received 29 June 2009 ,Accepted 6 September 2009.

References 

  1. United States Department of Health and Human Services (US DHHS) CfDCaPC, National Center for Health Statistics (NCHS) Bridged-Race Population Estimates, United States July 1st resident population by state, county, age, sex, bridged-race, and Hispanic origin, compiled from 1990-1999 bridged-race intercensal population estimates and 2000-2007 (Vintage 2007) bridged-race postcensal population estimates. CDC WONDER On-line Database. 2007 ed; 2007.
  2. Vouyouka AG, Kent KC. Arterial vascular disease in women. J Vasc Surg. 2007;46:1295–1302
  3. Henke PK, Proctor MC, Zajkowski PJ, Bedi A, Upchurch GR, Wakefield TW, et al. Tissue loss, early primary graft occlusion, female gender, and a prohibitive failure rate of secondary infrainguinal arterial reconstruction. J Vasc Surg. 2002;35:902–909
  4. Feinglass J, Kaushik S, Handel D, Kosifas A, Martin GJ, Pearce WH. Peripheral bypass surgery and amputation: northern Illinois demographics, 1993 to 1997. Arch Surg. 2000;135:75–80
  5. Magnant JG, Cronenwett JL, Walsh DB, Schneider JR, Besso SR, Zwolak RM. Surgical treatment of infrainguinal arterial occlusive disease in women. J Vasc Surg. 1993;17:67–76discussion 76-8
  6. Mays BW, Towne JB, Fitzpatrick CM, Smart SC, Cambria RA, Seabrook GR, et al. Women have increased risk of perioperative myocardial infarction and higher long-term mortality rates after lower extremity arterial bypass grafting. J Vasc Surg. 1999;29:807–812discussion 812-3
  7. Chang JK, Calligaro KD, Ryan S, Runyan D, Dougherty MJ, Stern JJ. Risk factors associated with infection of lower extremity revascularization: analysis of 365 procedures performed at a teaching hospital. Ann Vasc Surg. 2003;17:91–96
  8. McPhee JT, Hill JS, Eslami MH. The impact of gender on presentation, therapy, and mortality of abdominal aortic aneurysm in the United States, 2001-2004. J Vasc Surg. 2007;45:891–899
  9. Dillavou ED, Muluk SC, Makaroun MS. Improving aneurysm-related outcomes: nationwide benefits of endovascular repair. J Vasc Surg. 2006;43:446–451discussion 451-2
  10. Goldstein LJ, Khan HU, Sambol EB, Kent KC, Faries PL, Vouyouka AG. Carotid artery stenting is safe and associated with comparable outcomes in men and women. J Vasc Surg. 2009;49:315–323discussion 323-4
  11. Howard VJ, Voeks JH, Lutsep HL, Mackey A, Milot G, Sam AD, et al. Does sex matter? (Thirty-day stroke and death rates after carotid artery stenting in women versus men: results from the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) lead-in phase). Stroke. 2009;40:1140–1147
  12. Nowygrod R, Egorova N, Greco G, Anderson P, Gelijns A, Moskowitz A, et al. Trends, complications, and mortality in peripheral vascular surgery. J Vasc Surg. 2006;43:205–216
  13. Rowe VL, Lee W, Weaver FA, Etzioni D. Patterns of treatment for peripheral arterial disease in the United States: 1996-2005. J Vasc Surg. 2009;49:910–917
  14. Goodney PP, Beck AW, Nagle J, Welch HG, Zwolak RM. National trends in lower extremity bypass surgery, endovascular interventions, and major amputations. J Vasc Surg. 2009;50:54–60
  15. Stefanska A, Sypniewskay G, Senterkiewicz L. Inflammatory markers and cardiovascular risk in healthy polish women across the menopausal transition. Clin Chem. 2005;51:1893–1895
  16. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843
  17. Higgins J, Higgins J. Epidemiology of peripheral arterial disease in women. J Epidemiol. 2003;13:1–14
  18. Vogt MT, Cauley JA, Kuller LH, Hulley SB. Prevalence and correlates of lower extremity arterial disease in elderly women. Am J Epidemiol. 1993;137:559–568
  19. Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000. Circulation. 2004;110:738–743
  20. Zheng ZJ, Rosamond WD, Chambless LE, Nieto FJ, Barnes RW, Hutchinson RG, et al. Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Prev Med. 2005;29(5 suppl 1):42–49
  21. Beedon L, Wu KB. Women age 65 and older: their sources of income. Washington, DC: AARP Public Policy Institute; 2005;
  22. Houser AN. Women & long-term care research report. Washington, DC: AARP Public Policy Institute; 2007;
  23. Gabrel CS. An overview of nursing home facilities: data from the 1997 National Nursing Home Survey. http://www.cdc.gov/nchs/data/ad/ad311.pdfAccessed: Sept 17, 2009
  24. Vogt TM, Ross PD, Palermo L, Musliner T, Genant HK, Black D, et al. Vertebral fracture prevalence among women screened for the Fracture Intervention Trial and a simple clinical tool to screen for undiagnosed vertebral fractures (Fracture Intervention Trial Research Group). Mayo Clin Proc. 2000;75:888–896
  25. Vogt MT, Cauley JA, Kuller LH, Nevitt MC. Functional status and mobility among elderly women with lower extremity arterial disease: the Study of Osteoporotic Fractures. J Am Geriatr Soc. 1994;42:923–929
  26. Tunis SR, Bass EB, Klag MJ, Steinberg EP. Variation in utilization of procedures for treatment of peripheral arterial disease (A look at patient characteristics). Arch Intern Med. 1993;153:991–998
  27. Manheim LM, Sohn MW, Feinglass J, Ujiki M, Parker MA, Pearce WH. Hospital vascular surgery volume and procedure mortality rates in California, 1982-1994. J Vasc Surg. 1998;28:45–56discussion 56-8
  28. Dillavou ED, Muluk SC, Makaroun MS. A decade of change in abdominal aortic aneurysm repair in the United States: have we improved outcomes equally between men and women?. J Vasc Surg. 2006;43:230–238discussion 238
  29. Wolf YG, Arko FR, Hill BBOlcott Ct, Harris EJ, Fogarty TJ, Zarins CK. Gender differences in endovascular abdominal aortic aneurysm repair with the AneuRx stent graft. J Vasc Surg. 2002;35:882–886
  30. Ouriel K, Greenberg RK, Clair DG, O'Hara PJ, Srivastava SD, Lyden SP, et al. Endovascular aneurysm repair: gender-specific results. J Vasc Surg. 2003;38:93–98
  31. Lakdawalla D, Phillipson T. Aging and the growth of long-term care. Cambridge, MA: National Bureau of Economic Research (NBER); 1999;

 Competition of interest: Dr Marin is consulting for Medtronic.

 Additional material for this article may be found online at www.jvascsurg.org.

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(09)01836-9

doi: 10.1016/j.jvs.2009.09.006

Journal of Vascular Surgery
Volume 51, Issue 2 , Pages 372-378.e1 , February 2010