Journal of Vascular Surgery
Volume 50, Issue 6 , Pages 1348-1358.e3 , December 2009

A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency

This work was presented at the Thirty-first Charing Cross Symposium, London, United Kingdom, Apr 3-7, 2009.

  • Paolo Zamboni, MD

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • Corresponding Author InformationCorrespondence: Prof Paolo Zamboni, Director, Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    • ,
  • Roberto Galeotti, MD

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • ,
  • Erica Menegatti, RVT

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • ,
  • Anna Maria Malagoni, MD

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • ,
  • Sergio Gianesini, MD

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • ,
  • Ilaria Bartolomei, MD

      Affiliations

    • Department of Neurology, Bellaria Hospital, Bologna, Italy
    • ,
  • Francesco Mascoli, MD

      Affiliations

    • Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    • ,
  • Fabrizio Salvi, MD

      Affiliations

    • Department of Neurology, Bellaria Hospital, Bologna, Italy

Received 11 June 2009 ,Accepted 23 July 2009.

References 

  1. Schaller B. Physiology of cerebral venous blood flow: from experimental data in animals to normal function in humans. Brain Res Rev. 2004;46:243–260
  2. Menegatti E, Zamboni P. Doppler haemodynamics of cerebral venous return. Curr Neurovasc Res. 2008;5:260–265
  3. Lepori D, Capasso P, Fournier D, Genton CY, Schnyder P. High-resolution ultrasound evaluation of internal jugular venous valves. Eur Radiol. 1999;9:1222–1226
  4. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S, et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neur Neurosurg Psychiatry. 2009;80:392–399
  5. Lee BB, Laredo J, Lee TS, Huh S, Neville R. Terminology and classification of congenital vascular malformations. Phlebology. 2007;22:249–252
  6. Zamboni P, Menegatti E, Galeotti R, Malagoni AM, Tacconi G, Dall'ara S, et al. The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci. 2009;15:21–27
  7. Franceschi C. The unsolved puzzle of multiple sclerosis and venous function. J Neurol Neurosurg Psychiatry. 2009;80:358
  8. Zamboni P, Consorti G, Galeotti R, Gianesini S, Menegatti E, Tacconi G, et al. Venous collateral circulation of the extracranial cerebrospinal outflow routes. Curr Neurovasc Res. 2009;6:204–212
  9. Law M, Saindane AM, Ge Y, James SB, Glyn J, Lois JM, et al. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology. 2004;231:645–652
  10. Ge Y, Zohrabian VM, Grossman RI. Seven-Tesla magnetic resonance imaging (New vision of microvascular abnormalities in multiple sclerosis). Arch Neurol. 2008;65:812–816
  11. Kermode AG, Thompson AJ, Tofts P, MacManus DG, Kendall BE, Kingsley DP, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis (Pathogenetic and clinical implications). Brain. 1990;113:1477–1489
  12. Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T. Cortical lesions in multiple sclerosis. Brain. 1999;122:17–26
  13. Tan IL, van Schijndel RA, Pouwels PJ. MR venography of multiple sclerosis. Am J Neuroradiol. 2000;21:1039–1042
  14. Fog T. The topography of plaques in multiple sclerosis with special reference to cerebral plaques. Acta Neurol Scand Suppl. 1965;15:1–161
  15. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med. 2000;343:938–952
  16. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58:840–846
  17. Kurtzke JF. Rating neurological impairment in multiple sclerosis: an expanded disability scale (EDSS). Neurology. 1983;33:1444–1452
  18. Lee BB, Villavicencio L, Kim YW, Do YS, Koh KC, Lim HK, et al. Primary Budd-Chiari syndrome: outcome of endovascular management for suprahepatic venous obstruction. J Vasc Surg. 2006;43:101–108
  19. Raju S, Hollis K, Neglen P. Obstructive lesions of the inferior vena cava: clinical features and endovenous treatment. J Vasc Surg. 2006;44:820
  20. Viscusi ER, Reynolds L, Chung F, Atkinson LE, Khanna S. Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial. JAMA. 2004;17:1333–1341
  21. Cutter GR, Baier ML, Rudick RA, Cookfair DL, Fischer JS, Petkau J, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain. 1999;122:871–882
  22. Fisher JS, Rudick R, Cutter G, Reingold SC. The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment. Mult Scler. 1999;5:244–250
  23. D'Souza M, Kappos L, Czaplinski A. Reconsidering clinical outcomes in multiple sclerosis: relapses, impairment, disability and beyond. J Neurol Sci. 2008;274:76–79
  24. Weinstock-Guttman B, Ramanathan M, Zivadinov R. Interferon-beta treatment for relapsing multiple sclerosis. Expert Opin Biol Ther. 2008;8:1435–1447
  25. Freedman MS, Hughes B, Mikol DD, Bennett R, Cuffel B, Divan V, et al. Efficacy of disease-modifying therapies in relapsing remitting multiple sclerosis: a systematic comparison. Eur Neurol. 2008;60:1–11
  26. Vickrey BG, Hays RD, Harooni R, Myers LW, Ellison GW. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995;4:187–206
  27. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al. American College of Chest Physicians Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(6 suppl):381S–453S
  28. Zamboni P, Lanzara S, Mascoli F, Caggiati A, Liboni A. Inflammation in venous disease. Int Angiol. 2008;27:361–369
  29. Zamboni P. The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med. 2006;99:589–593
  30. Schelling F. Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses. 1986;21:141–148
  31. Talbert DG. Raised venous pressure as a factor in multiple sclerosis. Med Hypotheses. 2008;70:1112–1117
  32. West JB, Tsukimoto K, Matheu-Costello O, Prediletto R. Stress failure in pulmonary capillaries. J Appl Physiol. 1991;70:1731–1742
  33. Browse NL, Burnand KG. The cause of venous ulceration. Lancet. 1982;2:243–245
  34. Xu K, He FX, Zhang HG, Zhang XT, Han MJ, Wang CR, et al. Budd-Chiari syndrome caused by obstruction of the hepatic inferior vena cava: immediate and 2-year treatment results of transluminal angioplasty and metallic stent placement. Cardiovasc Intervent Radiol. 1996;19:32–36
  35. Havrdova E, Galetta S, Hutchinson M, Stefoski D, Bates D, Polman CH, et al. Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study. Lancet Neurol. 2009;8:254–260
  36. Coles AJ, Compston DA, Selmaj KW, Lake SL, Moran S, et al. CAMMS223 Trial Investigators Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N Engl J Med. 2008;359:1786–1801

 Competition of interest: none.

 Additional material for this article may be found online at www.jvascsurg.org.

 The editors and reviewers of this article have no relevant financial relationships to disclose per the JVS policy that requires reviewers to decline review of any manuscript for which they may have a competition of interest.

PII: S0741-5214(09)01568-7

doi: 10.1016/j.jvs.2009.07.096

Journal of Vascular Surgery
Volume 50, Issue 6 , Pages 1348-1358.e3 , December 2009

Article Tools

* Image Usage & Resolution