Journal of Vascular Surgery
Volume 49, Issue 6 , Pages 1465-1471 , June 2009

Concomitant coronary and peripheral arterial disease: Relationship between the inflammatory status of the affected limb and the severity of coronary artery disease

  • Gregorio Brevetti, MD

      Affiliations

    • Departments of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples “Federico II”, Naples, Italy
    • Corresponding Author InformationReprint requests: Gregorio Brevetti, MD, Via G. Iannelli 45/A, I-80131 Napoli, Italy
    • ,
  • Federico Piscione, MD

      Affiliations

    • Departments of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples “Federico II”, Naples, Italy
    • ,
  • Vittorio Schiano, MD

      Affiliations

    • Departments of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples “Federico II”, Naples, Italy
    • ,
  • Gennaro Galasso, MD

      Affiliations

    • Departments of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples “Federico II”, Naples, Italy
    • ,
  • Francesco Scopacasa, PhD

      Affiliations

    • Department of Laboratory Medicine, University of Naples “Federico II”, Naples, Italy
    • ,
  • Massimo Chiariello, MD

      Affiliations

    • Departments of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples “Federico II”, Naples, Italy

Received 7 January 2009 ,Accepted 9 February 2009.

References 

  1. Eagle KA, Rihal CS, Foster ED, Mickel MC, Gersh BJ. Long-term survival in patients with coronary artery disease: importance of peripheral vascular disease (The Coronary Artery Surgery Study (CASS) Investigators). J Am Coll Cardiol. 1994;23:1091–1095
  2. Krumholz HM, Chen J, Chen YT, Wang Y, Radford MJ. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. J Am Coll Cardiol. 2001;38:453–459
  3. Chiu JH, Topol EJ, Whitlow PL, Hsu AP, Tuzcu EM, Franco I, et al. Peripheral vascular disease and one-year mortality following percutaneous coronary revascularization. Am J Cardiol. 2003;92:582–583
  4. Narins CR, Zareba W, Moss AJ, Marder VJ, Ridker PM, Krone RJ, et al. Relationship between intermittent claudication, inflammation, thrombosis, and recurrent cardiac events among survivors of myocardial infarction. Arch Intern Med. 2004;164:440–446
  5. Brevetti G, Piscione F, Silvestro A, Galasso G, Di Donato A, Oliva G, et al. Increased inflammatory status and higher prevalence of three-vessel coronary artery disease in patients with concomitant coronary and peripheral atherosclerosis. Thromb Haemost. 2003;89:1058–1063
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  8. Brevetti G, Piscione F, Cirillo P, Galasso G, Schiano V, Barbato E, et al. In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunction. Atherosclerosis. 2008;201:440–446
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  10. Pasterkamp G, Schoneveld AH, van der Wal AC, Hijnen DJ, van Wolveren WJ, Plomp S, et al. Inflammation of the atherosclerotic cap and shoulder of the plaque is a common and locally observed feature in unruptured plaques of femoral and coronary arteries. Arterioscler Thromb Vasc Biol. 1999;19:54–58
  11. Vink A, Schoneveld AH, Richard W, de Kleijn DP, Falk E, Borst C, et al. Plaque burden, arterial remodeling and plaque vulnerability: determined by systemic factors?. J Am Coll Cardiol. 2001;38:718–723
  12. Maier W, Altwegg LA, Corti R, Gay S, Hersberger M, Maly FE, et al. Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation. 2005;111:1355–1361
  13. Nicholls SJ, Hazen SL. Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2005;25:1102–1111
  14. Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002;296:2391–2394
  15. Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, et al. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004;110:1134–1139
  16. Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Böhm M, et al. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res. 2004;94:534–541
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 Competition of interest: none.

PII: S0741-5214(09)00240-7

doi: 10.1016/j.jvs.2009.02.008

Journal of Vascular Surgery
Volume 49, Issue 6 , Pages 1465-1471 , June 2009

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