Concomitant coronary and peripheral arterial disease: Relationship between the inflammatory status of the affected limb and the severity of coronary artery disease

Venous-arterial differences in neutrophil myeloperoxidase (MPOx) content (A) and interleukin-6 (IL-6) (B) across femoral, coronary, and upper limb vascular beds. Data are expressed as medians, with 25th and 75th percentiles (boxes), and 10th and 90th percentiles (bars). In the coronary artery disease + peripheral arterial disease (CAD+PAD) group, the differences in MPOx content and IL-6 across the femoral circulation of the affected leg were significantly greater than that across the coronary circulation and the circulation of the upper limb. They were also greater than that across the femoral circulation of the healthy leg of CAD patients without PAD.

Coronary artery disease (CAD) severity in CAD-alone patients, and in the coronary artery disease + peripheral arterial disease (CAD+PAD) patients divided according to the median value of the transfemoral neutrophil myeloperoxidase (MPOx) content. Data concerning continuous variables (coronary artery endothelial function [CAEF] and number of significant coronary artery stenoses) are expressed as median (10th, 25th, 75th, and 90th percentile) while categorical variables (three-vessel CAD and previous myocardial infarction [MI]) as number of patients (%).

Coronary artery disease (CAD) severity in CAD-alone patients, and in the coronary artery disease + peripheral arterial disease (CAD+PAD) patients divided according to the median value of the venous-arterial difference in interleukin-6 (IL-6) plasma levels across the femoral circulation of the affected limb. Data concerning continuous variables (coronary artery endothelial function [CAEF] and number of significant coronary artery stenoses) are expressed as median (10th, 25th, 75th, and 90th percentile) while categorical variables (three-vessel CAD and previous myocardial infarction [MI]) as number of patients (%).