Journal of Vascular Surgery
Volume 50, Issue 1 , Pages 77-82 , July 2009

Sex differences in calf muscle hemoglobin oxygen saturation in patients with intermittent claudication

  • Andrew W. Gardner, PhD

      Affiliations

    • CMRI Diabetes and Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, Okla
    • Corresponding Author InformationReprint requests: Andrew W. Gardner, PhD, Hobbs-Recknagel Professor, General Clinical Research Center, University of Oklahoma Health Sciences Center, 1122 NE 13th St, Ste 150, Oklahoma City, OK 73117
    • ,
  • Donald E. Parker, PhD

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Okla
    • ,
  • Polly S. Montgomery, MS

      Affiliations

    • CMRI Diabetes and Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, Okla
    • ,
  • Steve M. Blevins, MD

      Affiliations

    • General Internal Medicine Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla
    • ,
  • Raha Nael, MD

      Affiliations

    • Cardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla
    • ,
  • Azhar Afaq, MD

      Affiliations

    • Endocrinology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla

Received 2 October 2008 ,Accepted 21 December 2008.

References 

  1. Brass EP, Hiatt WR. Review of mortality and cardiovascular event rates in patients enrolled in clinical trials for claudication therapies. Vasc Med. 2006;11:141–145
  2. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ, et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326:381–386
  3. Dormandy J, Heeck L, Vig S. The natural history of claudication: risk to life and limb. Semin Vasc Surg. 1999;12:123–137
  4. Muluk SC, Muluk VS, Kelley ME, Whittle JC, Tierney JA, Webster MW, et al. Outcome events in patients with claudication: a 15-year study in 2777 patients. J Vasc Surg. 2001;33:251–257
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  7. Kannel WB, McGee DL. Update on some epidemiologic features of intermittent claudication: the Framingham Study. J Am Geriatr Soc. 1985;33:13–18
  8. McDermott MM, Greenland P, Liu K, Criqui MH, Guralnik JM, Celic L, et al. Sex differences in peripheral arterial disease: leg symptoms and physical functioning. J Am Geriatr Soc. 2003;51:222–228
  9. Vogt MT, Cauley JA, Kuller LH, Nevitt MC. Functional status and mobility among elderly women with lower extremity arterial disease: the Study of Osteoporotic Fractures. J Am Geriatr Soc. 1994;42:923–929
  10. Gardner AW. Sex differences in claudication pain in subjects with peripheral arterial disease. Med Sci Sports Exerc. 2002;34:1695–1698
  11. McDermott MM, Mehta S, Greenland P. Exertional leg symptoms other than intermittent claudication are common in peripheral arterial disease. Arch Intern Med. 1999;159:387–392
  12. McDermott MM, Ferrucci L, Simonsick EM, Balfour J, Fried L, Ling S, et al. The ankle brachial index and change in lower extremity functioning over time: the Women's Health and Aging Study. J Am Geriatr Soc. 2002;50:238–246
  13. Afaq A, Montgomery PS, Scott KJ, Blevins SM, Whitsett TL, Gardner AW. The effect of current cigarette smoking on calf muscle hemoglobin oxygen saturation in patients with intermittent claudication. Vasc Med. 2007;12:167–173
  14. Gardner AW, Parker DE, Webb N, Montgomery PS, Scott KJ, Blevins SM. Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication. J Vasc Surg. 2008;48:644–649
  15. Mohler ER, Lech G, Supple GE, Wang H, Chance B. Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopy. Diabetes Care. 2006;29:1856–1859
  16. Komiyama T, Shigematsu H, Yasuhara H, Muto T. Near-infrared spectroscopy grades the severity of intermittent claudication in diabetics more accurately than ankle pressure measurement. Br J Surg. 2000;87:459–466
  17. Bauer TA, Brass EP, Hiatt WR. Impaired muscle oxygen use at onset of exercise in peripheral arterial disease. J Vasc Surg. 2004;40:488–493
  18. Bauer TA, Brass EP, Barstow TJ, Hiatt WR. Skeletal muscle StO2 kinetics are slowed during low work rate calf exercise in peripheral arterial disease. Eur J Appl Physiol. 2007;100:143–151
  19. Comerota AJ, Throm RC, Kelly P, Jaff M. Tissue (muscle) oxygen saturation (StO2): a new measure of symptomatic lower-extremity arterial disease. J Vasc Surg. 2003;38:724–729
  20. Komiyama T, Shigematsu H, Yasuhara H, Muto T. An objective assessment of intermittent claudication by near-infrared spectroscopy. Eur J Vasc Surg. 1994;8:294–296
  21. McCully KK, Halber C, Posner JD. Exercise-induced changes in oxygen saturation in the calf muscles of elderly subjects with peripheral vascular disease. J Gerontol. 1994;49:B128–B134
  22. Watanabe T, Matsushita M, Nishikimi N, Sakurai T, Komori K, Nimura Y. Near-infrared spectroscopy with treadmill exercise to assess lower limb ischemia in patients with atherosclerotic occlusive disease. Surg Today. 2004;34:849–854
  23. Lohman TC, Roche AF, Martorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books; 1988;39-70
  24. Gardner AW, Skinner JS, Cantwell BW, Smith LK. Progressive vs single-stage treadmill tests for evaluation of claudication. Med Sci Sports Exerc. 1991;23:402–408
  25. Gardner AW. Reliability of transcutaneous oximeter electrode heating power during exercise in patients with intermittent claudication. Angiology. 1997;48:229–235
  26. Gardner AW, Skinner JS, Smith LK. Effects of handrail support on claudication and hemodynamic responses to single-stage and progressive treadmill protocols in peripheral vascular occlusive disease. Am J Cardiol. 1991;68:99–105
  27. Feinberg RL, Gregory RT, Wheeler JR, Snyder SO, Gayle RG, Parent FN, et al. The ischemic window: a method for the objective quantitation of the training effect in exercise therapy for intermittent claudication. J Vasc Surg. 1992;16:244–250
  28. Montgomery PS, Gardner AW. The clinical utility of a six-minute walk test in peripheral arterial occlusive disease patients. J Am Geriatr Soc. 1998;46:706–711
  29. Regensteiner JG, Steiner JF, Panzer RL, Hiatt WR. Evaluation of walking impairment by questionnaire in patients with peripheral arterial disease. J Vasc Med Biol. 1990;2:142–152
  30. Gardner AW, Montgomery PS, Scott KJ, Afaq A, Blevins SM. Patterns of ambulatory activity in subjects with and without intermittent claudication. J Vasc Surg. 2007;46:1208–1214
  31. Ryan AS, Katzel LI, Gardner AW. Determinants of peak V(O2) in peripheral arterial occlusive disease patients. J Gerontol A Biol Sci Med Sci. 2000;55:B302–B306

 This research was supported by grants from the National Institute on Aging (NIA) (R01-AG-24296) to Dr Gardner, by a Oklahoma Center for the Advancement of Science and Technology grant (HR04-113S) to Dr Gardner, and by the University of Oklahoma Health Sciences Center General Clinical Research Center grant (M01-RR-14467), sponsored by the National Center for Research Resources from the National Institutes of Health.

 Competition of interest: none.

PII: S0741-5214(08)02304-5

doi: 10.1016/j.jvs.2008.12.065

Journal of Vascular Surgery
Volume 50, Issue 1 , Pages 77-82 , July 2009

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