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Journal of Vascular Surgery
Volume 50, Issue 1
, Pages 23-29
, July 2009
The effect of azithromycin and Chlamydophilia pneumonia infection on expansion of small abdominal aortic aneurysms - A prospective randomized double-blind trial
References
- . Pathogenesis of abdominal aortic aneurysms - cellular and biochemical mechanisms. Eur J Vasc Endovasc Surg. 1996;12:391–400
- . Metalloproteinases in degenerative aortic disease. Clin Sci (Lond). 1991;81:233–239
- . Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc Natl Acad Sci USA. 1995;92:6911–6914
- Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms. J Vasc Surg. 1997;25:499–505
- . Detection of viable Chlamydia pneumoniae in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2000;19:630–635
- . Distribution of Chlamydia pneumoniae in the human arterial system and its relation to the local amount of atherosclerosis within the individual. Circulation. 2001;103:1613–1617
- . Structure and function of immunoglobulin A. Prog Allergy. 1972;16:181–213
- . Persistent Chlamydia pneumoniae infection in a Swedish family. Scand J Infect Dis. 1996;28:271–273
- . Indicators of infection with Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms. J Vasc Surg. 2001;34:212–215
- . Can an antibiotic (macrolide) prevent Chlamydia pneumoniae- induced atherosclerosis in a rabbit model?. Clin Diagn Lab Immunol. 1999;6:891–894
- . Chlamydia pneumoniae antigens facilitate experimental aortic dilatation: prevention with azithromycin. J Vasc Surg. 2002;36:1011–1017
- . Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study. J Vasc Surg. 2001;34:606–610
- . Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion. Br J Surg. 2001;88:1066–1072
- . Aspirin inhibits Chlamydia pneumoniae-induced nuclear factor-kappa B activation, cytokine expression, and bacterial development in human endothelial cells. Arterioscler Thromb Vasc Biol. 2002;22:1075–1080
- Simvastatin suppresses experimental aortic aneurysm expansion. J Vasc Surg. 2006;43:117–124
- . Serological analysis of specific IgA to Chlamydia pneumoniae: increased sensitivity of IgA antibody detection using prolonged incubation and high antigen concentration. APMIS. 2000;108:357–362
- . Comparison of a new commercial EIA kit and the microimmunofluorescence technique for determination of IgG and IgA antibodies to Chlamydia pneumoniae. APMIS. 2000;108:819–824
- R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.
- . Provocation of experimental aortic inflammation and dilatation by inflammatory mediators and Chlamydia pneumoniae. Br J Surg. 2001;88:935–940
- . Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections. J Antimicrob Chemother. 2001;48:691–703
- . Effect of azithromycin treatment on endothelial function in patients with coronary artery disease and evidence of Chlamydia pneumoniae infection. Circulation. 2002;105:1298–1303
- . A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis. 1990;161:618–625
- . Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect Immun. 1996;64:1614–1620
- . Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest. 1995;96:2569–2577
- . Tobacco smoke induces persistent infection of Chlamydia pneumoniae in HEp-2 cells. Microb Pathog. 2004;37:141–148
- . First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae. Antimicrob Agents Chemother. 2004;48:1402–1405
- . Smokers‘ relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J Vasc Surg. 2003;38:329–334
- . Smoking and growth rate of small aortic aneurysms. Lancet. 1994;344:651–652
- . Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet. 1998;352:1649–1655
- . Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation. 2004;110:16–21
- . Smoking, but not lipids, lipoprotein(a) and antibodies against oxidised LDL, is correlated to the expansion of abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2001;21:51–56
- . Prevalence of coronary artery disease, lower extremity peripheral arterial disease, and cerebrovascular disease in 110 men with an abdominal aortic aneurysm. Am J Cardiol. 2004;94:1358–1359
- . J Vasc Surg. 2008;47:1127–1133
- Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. Eur J Vasc Endovasc Surg. 2006;32:21–26
- . Simvastatin attenuates the activity of matrix metalloproteinase-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg. 2007;34:302–303
- . Vascular surgical society of Great Britain and Ireland: non steroidal anti-inflammatory drugs to treat abdominal aortic aneurysm. Br J Surg. 1999;86:707
- . Chlamydia pneumoniae but not cytomegalovirus antibodies are associated with future risk of stroke and cardiovascular disease: a prospective study in middle-aged to elderly men with treated hypertension. Stroke. 1999;30:299–305
The Research was supported by grants from County of Gävleborg Research and Development Center (FoU), Gore Swedish Research Foundation, Pfizer AB Sweden, Schyberg medical research fund, and Zoega medical research fund. We thank Prof Martin Björck for initial funding for the CT scans.
Competition of interest: none.
PII: S0741-5214(08)02287-8
doi: 10.1016/j.jvs.2008.12.048
© 2009 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.
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Journal of Vascular Surgery
Volume 50, Issue 1
, Pages 23-29
, July 2009
