Journal of Vascular Surgery
Volume 49, Issue 5 , Pages 1140-1146 , May 2009

Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair

  • Catherine K. Chang, MD

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif
    • ,
  • Timothy A.M. Chuter, MD

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif
    • ,
  • Claus U. Niemann, MD

      Affiliations

    • Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, Calif
    • University of California at San Francisco, San Francisco, Calif
    • ,
  • Michael G. Shlipak, MD

      Affiliations

    • General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Mitchell J. Cohen, MD

      Affiliations

    • Department of Surgery, Division of Transplantation, University of California at San Francisco, San Francisco, Calif
    • ,
  • Linda M. Reilly, MD

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif
    • ,
  • Jade S. Hiramoto, MD

      Affiliations

    • Department of Surgery, Division of Vascular Surgery, University of California at San Francisco, San Francisco, Calif
    • Corresponding Author InformationReprint requests: Jade S. Hiramoto, MD, University of California, San Francisco, Division of Vascular Surgery, 400 Parnassus Ave, A-581, San Francisco, CA 94143-0222

Received 13 September 2008 ,Accepted 29 November 2008.

  • Image Result

    Computed tomographic angiography with three-dimensional reconstruction after multi-branched endovascular thoracoabdominal aortic aneurysm (TAAA) repair.

    Computed tomographic angiography with three-dimensional reconstruction after multi-branched endovascular thoracoabdominal aortic aneurysm (TAAA) repair.

  • Image Result

    Comparison of changes in white blood cell (WBC) and platelet count after endovascular thoracoabdominal aortic aneurysm (TAAA) repair between patients with and without postoperative renal insufficiency

    Comparison of changes in white blood cell (WBC) and platelet count after endovascular thoracoabdominal aortic aneurysm (TAAA) repair between patients with and without postoperative renal insufficiency.

  • Image Result
    A, Univariate linear regression of postoperative change in serum creatinine using change in white blood cell (WBC) as the predictor variable B, Univariate linear regression of postoperative change in

    A, Univariate linear regression of postoperative change in serum creatinine using change in white blood cell (WBC) as the predictor variable B, Univariate linear regression of postoperative change in serum creatinine using change in platelet count as the predictor variable.

  • Image Result
    A, Rise in neutrophil gelatinase-associated lipocalin (NGAL) levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9). B, Rise in cystatin C levels over time foll

    A, Rise in neutrophil gelatinase-associated lipocalin (NGAL) levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9). B, Rise in cystatin C levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9).

  • Image Result
    Rise in interleukin-6 (IL-6) levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9).

    Rise in interleukin-6 (IL-6) levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9).

  • Image Result
    A, Fall in factor V and protein C levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9). B, Rise in d-dimer levels over time following endovascular thoracoabdo

    A, Fall in factor V and protein C levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9). B, Rise in d-dimer levels over time following endovascular thoracoabdominal aortic aneurysm (TAAA) repair (n = 9).

 This project was supported by National Institutes of Health (NIH)/National Center for Research Resources (NCRR)/OD University of California, San Francisco (UCSF)-Clinical and Translational Science Institute (CTSI) Grant Number KL2 RR024130 (Dr Hiramoto) and NIH K08 GM-085689 (Dr Cohen). Its contents are the responsibility of the authors and do not necessarily represent the official views of the NIH. This study was also supported in part by grants from the Hellman Award, San Francisco, CA (Dr Hiramoto); the Research Evaluation and Allocation Committee, San Francisco, CA (Dr Hiramoto); the Foundation of Anesthesia Research and Education, Rochester, MN (Dr Niemann); the International Anesthesia Research Society, Cleveland, OH (Dr Niemann); the Foundation for Accelerated Vascular Research, San Francisco, CA (Drs Chang and Chuter); and the Established Investigator Award from the American Heart Association (Dr Shlipak). The Clinicaltrials.gov number is: NCT00483249.

 Conflict of interest: Dr. Chuter has licensed patents to Cook Medical, Inc. and receives travel and research support from Cook Medical, Inc.

PII: S0741-5214(08)02111-3

doi: 10.1016/j.jvs.2008.11.102

Journal of Vascular Surgery
Volume 49, Issue 5 , Pages 1140-1146 , May 2009

Article Tools

* Image Usage & Resolution