Journal of Vascular Surgery
Volume 48, Issue 6, Supplement , Pages 53S-60S , December 2008

Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells

Received 11 July 2008 ,Accepted 4 September 2008.

References 

  1. Risau W. Mechanisms of angiogenesis. Nature. 1997;86:671–674
  2. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653–660
  3. Schaper W, Buschmann I. Collateral circulation and diabetes. Circulation. 1999;99:2224–2226
  4. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic–helix loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92:5510–5514
  5. Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding and transactivation properties of hypoxia inducible factor 1. J Biol Chem. 1996;271:17771–17778
  6. Gale NW, Yancopoulos GD. Growth factors acting via endothelial cell specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999;13:1055–1066
  7. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular permeability and angiogenesis. Am J Pathol. 1995;146:1029–1039
  8. Nabel EG, Yang Zy, Plautz G, Forough R, Zhanx , Haudenschild CC, et al. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nature. 1993;362:844–846
  9. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, et al. Angiopoietin–1 protects the adult vasculature against plasma leakage. Nat Med. 2000;6:460–463
  10. Hirschi K, Rohovsky S, D'Amore P. PDGF, TGF-b and heterotypic cell-cell interactions mediate endothelial cell induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol. 1998;141:805–814
  11. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 2002;8:831–840
  12. Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Tsutsumi Y, Ozono R, et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands and cytokines. Circulation. 2001;104:1046–1052
  13. Shintani S, Murohara T, Ikeda H, Veno T, Sasaki K, Dvan J. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation. 2001;103:897-5
  14. Qvirici N, Soligo D, Caneva L, Servida F, Bossolasco T, Lambertenghi G. Differentiation and expansion of endothelial cells from human bone marrow CD 133+ cells. Br J Haematol. 2001;115:186–194
  15. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964–967
  16. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane UJ, Williams M. Expression of VEGFR-2 and AC 133 by circulating human CD 34+ cells identifies a population of functional endothelial precursors. Blood. 2000;95:952–958
  17. Li TS, Hamano K, Nishida M, Hayashi M, Ito H, Mikamo A, et al. CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation. Am J Physiol Heart Care Physiol. 2003;285:H931–H937
  18. Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, Nakagawa K. Autologous bone marrow mononuclear cell implantation improves endothelium dependant vasodilation in patients with limb ischemia. Circulation. 2004;109:1215–1218
  19. Saigawa T, Kato K, Ozawa T, Toba K, Makiyama Y, Mingawa S. Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans and the association between efficacy and the number of implanted bone marrow cells. Circ J. 2004;68:1189–1193
  20. Olin JW. Thromboangiitis obliterans (Buerger's disease). N Engl J Med. 2000;343:864–869
  21. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, et al. Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone marrow cells: a pilot study and a randomized controlled trial. Lancet. 2002;360:427–435
  22. Asahara T, Kawamoto A. Endothelial progenitor cells for postnatal vasculogenesis. Am J Physiol Cell Physiol. 2004;287:C572–C579
  23. Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest. 1999;103:1231–1236
  24. Kinnaird T, Stabile E, Burnett MS, Epstein SE. Bone marrow derived cells for enhancing collateral development. Circulation. 2004;95:354–363
  25. Borner C, Heidrich H. long-term follow-up of thromboangiitis obliterans. Vasa. 1998;27:80–86

 STATEMENT OF CONFLICT OF INTEREST: These authors report that they have no conflicts of interest with the sponsor of this supplement article or products discussed in this article.

PII: S0741-5214(08)01519-X

doi: 10.1016/j.jvs.2008.09.005

Journal of Vascular Surgery
Volume 48, Issue 6, Supplement , Pages 53S-60S , December 2008

Article Tools

* Image Usage & Resolution