Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells

A grid was created over calf muscles and bone marrow mononuclear cells were injected in 30 to 40 sites.

Strongyloides stercoralis was found in the bone marrow aspirate of one patient.

This patient had severe hand ischemia with nonreconstructible thromboangiitis obliterans.

A, Toe amputation site after failed vascular reconstruction and B, 5 weeks after therapy.

A, Representation of the mean ankle-brachial index and standard error (bars). B, Representation of individual subject data for the ankle-brachial index.

A, Representation of visual analog scale data and standard error (bars). B, Representation of individual subject data on the visual analog scale.

A, Representation of mean transcutaneous oximetry data and the standard error (bars). B, Representation of individual subject data for transcutaneous oximetry levels.