Journal of Vascular Surgery
Volume 49, Issue 1 , Pages 47-51 , January 2009

A population-based case-control study of the familial risk of abdominal aortic aneurysm

Presented at the Sixty-second Vascular Annual Meeting, San Diego, Calif, Jun 4-8, 2008.

  • Emma Larsson, MD

      Affiliations

    • Department of Molecular Medicine and Surgery, Stockholm, Sweden
    • Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden
    • Corresponding Author InformationCorrespondence: Emma Larsson, MD, Department of Vascular Surgery, N2:06, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Fredrik Granath, PhD, Asst. Prof

      Affiliations

    • Department of Internal Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Jesper Swedenborg, MD, PhD

      Affiliations

    • Department of Molecular Medicine and Surgery, Stockholm, Sweden
    • Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Rebecka Hultgren, MD, PhD

      Affiliations

    • Department of Molecular Medicine and Surgery, Stockholm, Sweden
    • Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden

Received 1 June 2008 ,Accepted 6 August 2008.

References 

  1. Clifton MA. Familial abdominal aortic aneurysms. Br J Surg. 1977;64:765–766
  2. Ogata T, MacKean GL, Cole CW, Arthur C, Andreou P, Tromp G, et al. The lifetime prevalence of abdominal aortic aneurysms among siblings of aneurysm patients is eightfold higher than among siblings of spouses: an analysis of 187 aneurysm families in Nova Scotia, Canada. J Vasc Surg. 2005;42:891–897
  3. Frydman G, Walker PJ, Summers K, West M, Xu D, Lightfoot T, et al. The value of screening in siblings of patients with abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2003;26:396–400
  4. Adamson J, Powell JT, Greenhalgh RM. Selection for screening for familial aortic aneurysms. Br J Surg. 1992;79:897–898
  5. Blanchard JF, Armenian HK, Friesen PP. Risk factors for abdominal aortic aneurysm: results of a case-control study. Am J Epidemiol. 2000;151:575–583
  6. Salo JA, Soisalon-Soininen S, Bondestam S, Mattila PS. Familial occurrence of abdominal aortic aneurysm. Ann Intern Med. 1999;130:637–642
  7. Darling RC, Brewster DC, Darling RC, LaMuraglia GM, Moncure AC, Cambria RP, et al. Are familial abdominal aortic aneurysms different?. J Vasc Surg. 1989;10:39–43
  8. Le Hello C, Koskas F, Cluzel P, Tazi Z, Gallos C, Piette JC, et al. French women from multiplex abdominal aortic aneurysm families should be screened. Ann Surg. 2005;242:739–744
  9. Pleumeekers HJ, Hoes AW, van der Does E, van Urk H, Hofman A, de Jong PT, et al. Aneurysms of the abdominal aorta in older adults (The Rotterdam Study). Am J Epidemiol. 1995;142:1291–1299
  10. Dueck AD, Johnston KW, Alter D, Laupacis A, Kucey DS. Predictors of repair and effect of gender on treatment of ruptured abdominal aortic aneurysm. J Vasc Surg. 2004;39:784–787
  11. Baird PA, Sadovnick AD, Yee IM, Cole CW, Cole L. Sibling risks of abdominal aortic aneurysm. Lancet. 1995;346:601–604
  12. Hemminki K, Li X, Johansson SE, Sundquist K, Sundquist J. Familial risks of aortic aneurysms among siblings in a nationwide Swedish study. Genet Med. 2006;8:43–49
  13. Badger SA, O'Donnell ME, Boyd CS, Hannon RJ, Lau LL, Lee B, et al. The low prevalence of abdominal aortic aneurysm in relatives in Northern Ireland. Eur J Vasc Endovasc Surg. 2007;34:163–168
  14. Helgadottir A, Thorleifsson G, Magnusson KP, Gretarsdottir S, Steinthorsdottir V, Manolescu A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm, and intracranial aneurysm. Nat Genet. 2008;40:217–224
  15. Kuivaniemi H, Shibamura H, Arthur C, Berguer R, Cole CW, Juvonen T, et al. Familial abdominal aortic aneurysms: collection of 233 multiplex families. J Vasc Surg. 2003;37:340–345
  16. Lee AJ, Fowkes FG, Carson MN, Leng GC, Allan PL. Smoking, atherosclerosis, and risk of abdominal aortic aneurysm. Eur Heart J. 1997;18:671–676

 The study was funded by financial support provided by the Swedish Heart-Lung Foundation (Go Red), by the European Society of Vascular Surgery, and through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and the Karolinska Institutet.

 Competition of interest: none.

PII: S0741-5214(08)01362-1

doi: 10.1016/j.jvs.2008.08.012

Journal of Vascular Surgery
Volume 49, Issue 1 , Pages 47-51 , January 2009

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