Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1458-1463 , December 2008

Histopathological comparison between endofibrosis of the high-performance cyclist and atherosclerosis in the external iliac artery

  • Aryan Vink, MD, PhD

      Affiliations

    • Department of Pathology, University Medical Center, Utrecht, The Netherlands
    • Corresponding Author InformationCorrespondence: Aryan Vink, MD, University Medical Center Utrecht, Department of Pathology, Room H04-312, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    • ,
  • Mart H. Bender, MD

      Affiliations

    • Department of Surgery, Maxima Medical Center, Veldhoven, The Netherlands
    • ,
  • Goof Schep, MD, PhD

      Affiliations

    • Department of Sports Medicine, Maxima Medical Center, Veldhoven, The Netherlands
    • ,
  • Dick F. van Wichen, BSc

      Affiliations

    • Department of Pathology, University Medical Center, Utrecht, The Netherlands
    • ,
  • Roel A. de Weger, PhD

      Affiliations

    • Department of Pathology, University Medical Center, Utrecht, The Netherlands
    • ,
  • Gerard Pasterkamp, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    • ,
  • Frans L. Moll, MD, PhD

      Affiliations

    • Department of Surgery, University Medical Center, Utrecht, The Netherlands

Received 5 June 2008 ,Accepted 16 July 2008.

References 

  1. Walder J, Mosimann F, Van Melle G, Mosimann R. A propos de l'endofibrose iliaque chez deux coureurs cyclistes. Helv Chir Acta. 1985;51:793–795
  2. Chevalier JM, Enon B, Walder J, Barral X, Pillet J, Megret A, et al. Endofibrosis of the external iliac artery in bicycle racers: an unrecognized pathological state. Ann Vasc Surg. 1986;1:297–303
  3. Rousselet MC, Saint-Andre JP, L'Hoste P, Enon B, Megret A, Chevalier JM. Stenotic intimal thickening of the external iliac artery in competition cyclists. Hum Pathol. 1990;21:524–529
  4. Bender MH, Schep G, de Vries WR, Hoogeveen AR, Wijn PF. Sports-related flow limitations in the iliac arteries in endurance athletes: aetiology, diagnosis, treatment, and future developments. Sports Med. 2004;34:427–442
  5. Schep G, Bender MH, van de Tempel G, Wijn PF, de Vries WR, Eikelboom BC. Detection and treatment of claudication due to functional iliac obstruction in top endurance athletes: a prospective study. Lancet. 2002;359:466–473
  6. Vink A, Schoneveld AH, Poppen M, de Kleijn DP, Borst C, Pasterkamp G. Morphometric and immunohistochemical characterization of the intimal layer throughout the arterial system of elderly humans. J Anat. 2002;200:97–103
  7. Vink A, Schoneveld AH, Richard W, de Kleijn DP, Falk E, Borst C, et al. Plaque burden, arterial remodeling, and plaque vulnerability: determined by systemic factors?. J Am Coll Cardiol. 2001;38:718–723
  8. Abraham P, Chevalier JM, Loire R, Saumet JL. External iliac artery endofibrosis in a young cyclist. Circulation. 1999;100:e38
  9. Kral CA, Han DC, Edwards WD, Spittell PC, Tazelaar HD, Cherry KJ. Obstructive external iliac arteriopathy in avid bicyclists: new and variable histopathologic features in four women. J Vasc Surg. 2002;36:565–570
  10. Scavèe V, Stainier L, Deltombe T, Theys S, Delos M, Trigaux JP, et al. External iliac artery endofibrosis: a new possible predisposing factor. J Vasc Surg. 2003;38:180–182
  11. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275
  12. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657–671
  13. Sluimer JC, Kisters N, Cleutjens KB, Volger OL, Horrevoets AJ, van den Akker LH, et al. Dead or alive: gene expression profiles of advanced atherosclerotic plaques from autopsy and surgery. Physiol Genomics. 2007;30:335–341

 Competition of interest: none.

PII: S0741-5214(08)01195-6

doi: 10.1016/j.jvs.2008.07.057

Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1458-1463 , December 2008

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