Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1509-1513 , December 2008

Integrity of venoarteriolar reflex determines level of microvascular skin flow enhancement with intermittent pneumatic compression

  • Marc Husmann, MD

      Affiliations

    • Division of Angiology, University Hospital Bern, Bern, Switzerland
    • Division of Angiology, University Hospital Zurich, Zurich, Switzerland
    • Corresponding Author InformationReprint requests: Marc Husmann, MD, Angiology Division, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    • ,
  • Torsten Willenberg, MD

      Affiliations

    • Division of Angiology, University Hospital Bern, Bern, Switzerland
    • ,
  • Hak Hong Keo, MD

      Affiliations

    • Division of Angiology, University Hospital Bern, Bern, Switzerland
    • ,
  • Silviana Spring, MD

      Affiliations

    • Division of Angiology, University Hospital Zurich, Zurich, Switzerland
    • ,
  • Evi Kalodiki, MD, PhD

      Affiliations

    • Imperial College School of Medicine, Zurich, Switzerland
    • ,
  • Kostas T. Delis, MSc, MD, MS, PhD

      Affiliations

    • Department of Vascular Surgery, Athens Medical Center, Marousi, Athens, Greece

Received 1 May 2008 ,Accepted 10 July 2008.

References 

  1. Eze AR, Comerota AJ, Cisek PL, Holland BS, Kerr RP, Veeramasuneni R, et al. Intermittent calf and foot compression increases lower extremity blood flow. Am J Surg. 1996;172:130–134discussion 135
  2. Kavros SJ, Delis KT, Turner NS, Voll AE, Liedl DA, Gloviczki P, et al. Improving limb salvage in critical ischemia with intermittent pneumatic compression: a controlled study with 18-month follow-up. J Vasc Surg. 2008;47:543–549
  3. van Bemmelen PS, Mattos MA, Faught WE, Mansour MA, Barkmeier LD, Hodgson KJ, et al. Augmentation of blood flow in limbs with occlusive arterial disease by intermittent calf compression. J Vasc Surg. 1994;19:1052–1058
  4. Abu-Own A, Cheatle T, Scurr JH, Coleridge Smith PD. Effects of intermittent pneumatic compression of the foot on the microcirculatory function in arterial disease. Eur J Vasc Surg. 1993;7:488–492
  5. Labropoulos N, Leon LR, Bhatti A, Melton S, Kang SS, Mansour AM, et al. Hemodynamic effects of intermittent pneumatic compression in patients with critical limb ischemia. J Vasc Surg. 2005;42:710–716
  6. Delis KT, Knaggs AL. Duration and amplitude decay of acute arterial leg inflow enhancement with intermittent pneumatic leg compression: an insight into the implicated physiologic mechanisms. J Vasc Surg. 2005;42(4):717–725
  7. Labropoulos N, Cunningham J, Kang SS, Mansour MA, Baker WH. Optimising the performance of intermittent pneumatic compression devices. Eur J Vasc Endovasc Surg. 2000;19:593–597
  8. Belcaro G, Vasdekis S, Rulo A, Nicolaides AN. Evaluation of skin blood flow and venoarteriolar response in patients with diabetes and peripheral vascular disease by laser Doppler flowmetry. Angiology. 1989;40:953–957
  9. Delis KT, GiannouKas AD. Intermittent pneumatic compression (IPC) in the treatment of peripheral arterial occlusive disease (PAOD) (A useful tool or just another device?). Eur J Vasc Endovasc Surg. 2007;33:309–310
  10. Henriksen O. Local nervous mechanism in regulation of blood flow in human subcutaneous tissue. Acta Physiol Scand. 1976;97:385–391
  11. Henriksen O. Orthostatic changes of blood flow in subcutaneous tissue in patients with arterial insufficiency of the legs. Scand J Clin Lab Invest. 1974;34:103–109
  12. Henriksen O, Nielsen SL, Paaske WP, Sejrsen P. Autoregulation of blood flow in human cutaneous tissue. Acta Physiol Scand. 1973;89:538–543
  13. Wahlberg E, Jorneskog G, Olofsson P, Swedenborg J, Fagrell B. The influence of reactive hyperemia and leg dependency on skin microcirculation in patients with peripheral arterial occlusive disease (PAOD), with and without diabetes. Vasa. 1990;19:301–306
  14. Cisek PL, Eze AR, Comerota AJ, Kerr R, Brake B, Kelly P. Microcirculatory compensation to progressive atherosclerotic disease. Ann Vasc Surg. 1997;11:49–53
  15. Zierler RE. Duplex and color-flow imaging of the lower extremity arterial circulation. Semin Ultrasound CT MR. 1990;11:168–179
  16. Zierler RE, Zierler BK. Duplex sonography of lower extremity arteries. Semin Ultrasound CT MR. 1997;18:39–56
  17. Delis KT, Lennox AF, Nicolaides AN, Wolfe JH. Sympathetic autoregulation in peripheral vascular disease. Br J Surg. 2001;88:523–528
  18. Husmann MJ, Barton M, Jacomella V, Silvestro A, Amann-Vesti BR. Long-term effects of endovascular angioplasty on orthostatic vasocutaneous autoregulation in patients with peripheral atherosclerosis. J Vasc Surg. 2006;44:993–997
  19. Midttun M, Sejrsen P, Paaske WP. Blood flow rate during orthostatic pressure changes in the pulp skin of the first toe. Eur J Vasc Endovasc Surg. 1997;13:278–284
  20. Delis KT, Husmann MJ, Cheshire NJ, Nicolaides AN. Effects of intermittent pneumatic compression of the calf and thigh on arterial calf inflow: a study of normals, claudicants, and grafted arteriopaths. Surgery. 2001;129:188–195
  21. Delis KT, Husmann MJ, Nicolaides AN, Wolfe JH, Cheshire NJ. Enhancing foot skin blood flux in peripheral vascular disease using intermittent pneumatic compression: controlled study on claudicants and grafted arteriopaths. World J Surg. 2002;26:861–866
  22. Delis KT, Husmann MJ, Szendro G, Peters NS, Wolfe JH, Mansfield AO. Haemodynamic effect of intermittent pneumatic compression of the leg after infrainguinal arterial bypass grafting. Br J Surg. 2004;91:429–434
  23. Chen LE, Liu K, Qi WN, Joneschild E, Tan X, Seaber AV, et al. Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. J Appl Physiol. 2002;92:559–566
  24. Dai G, Tsukurov O, Orkin RW, Abbott WM, Kamm RD, Gertler JP. An in vitro cell culture system to study the influence of external pneumatic compression on endothelial function. J Vasc Surg. 2000;32:977–987
  25. Eickhoff JH, Engell HC. Local regulation of blood flow and the occurrence of edema after arterial reconstruction of the lower limbs. Ann Surg. 1982;195:474–478
  26. Caspary LA, Creutzig A, Alexander K. Orthostatic vasoconstrictor response in patients with occlusive arterial disease assessed by laser Doppler flux and transcutaneous oximetry. Angiology. 1996;47:165–173
  27. Jensen K, Andersen K, Smith T, Henriksen O, Melgaard B. Sympathetic vasoconstrictor nerve function in alcoholic neuropathy. Clin Physiol. 1984;4:253–262
  28. Belcaro G, Grigg M, Rulo A, Nicolaides A. Blood flow in the perimalleolar skin in relation to posture in patients with venous hypertension. Ann Vasc Surg. 1989;3:5–7
  29. Gorter PM, Olijhoek JK, van der Graaf Y, Algra A, Rabelink TJ, Visseren FL. Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm. Atherosclerosis. 2004;173:363–369
  30. Mannava K, Money SR. Current management of peripheral arterial occlusive disease: a review of pharmacologic agents and other interventions. Am J Cardiovasc Drugs. 2007;7:59–66
  31. Delis KT, Nicolaides AN. Effect of intermittent pneumatic compression of foot and calf on walking distance, hemodynamics, and quality of life in patients with arterial claudication (A prospective randomized controlled study with 1-year follow-up). Ann Surg. 2005;241(3):431–441
  32. Mendoza MG, Robles HV, Romo E, Rios A, Escalante B. Nitric oxide-dependent neovascularization role in the lower extremity disease. Curr Pharm Des. 2007;13:3591–3596
  33. Lee HJ, Koh GY. Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cells. Biochem Biophys Res Commun. 2003;304:399–404
  34. Li S. Analysis of endothelial cell migration under flow. Methods Mol Biol. 2005;294:107–121

 Supported by the Swiss Heart Foundation and the Roche Science Foundation.

 Competition of interest: none.

PII: S0741-5214(08)01173-7

doi: 10.1016/j.jvs.2008.07.016

Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1509-1513 , December 2008

Article Tools

* Image Usage & Resolution