Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1532-1537 , December 2008

The quantitative benefit of isolated, segmental, pharmacomechanical thrombolysis (ISPMT) for iliofemoral venous thrombosis

Presented at the American Venous Forum Twentieth Annual Meeting, Feb 20-23, 2008, Charleston, SC.

  • Jorge L. Martinez Trabal, MD

      Affiliations

    • Section of Vascular Surgery, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio
    • ,
  • Anthony J. Comerota, MD

      Affiliations

    • Section of Vascular Surgery, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio
    • Corresponding Author InformationCorrespondence: Anthony J. Comerota, MD, Director, Jobst Vascular Center, The Toledo Hospital, 2109 Hughes Dr, Suite 400, Toledo, OH 43606
    • ,
  • Frankie B. LaPorte, MS

      Affiliations

    • Section of Vascular Surgery, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio
    • ,
  • Sahira Kazanjian, MD

      Affiliations

    • Section of Interventional Radiology, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio
    • ,
  • Robert DiSalle, MD

      Affiliations

    • Section of Interventional Radiology, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio
    • ,
  • Deborah M. Sepanski, RT(R)CV

      Affiliations

    • Section of Interventional Radiology, Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio

Received 11 March 2008 ,Accepted 2 July 2008.

References 

  1. O'Donnell TF, Browse NL, Burnand KG, Thomas ML. The socioeconomic effects of an iliofemoral venous thrombosis. J Surg Res. 1977;22:483–488
  2. Akesson H, Brudin L, Dahlstrom JA, Eklof B, Ohlin P, Plate G. Venous function assessed during a 5 year period after acute ilio-femoral venous thrombosis treated with anticoagulation. Eur J Vasc Surg. 1990;4:43–48
  3. Delis KT, Bountouroglou D, Mansfield AO. Venous claudication in iliofemoral thrombosis: long-term effects on venous hemodynamics, clinical status, and quality of life. Ann Surg. 2004;239:118–126
  4. Meissner MH, Manzo RA, Bergelin RO, Markel A, Strandness DE. Deep venous insufficiency: the relationship between lysis and subsequent reflux. J Vasc Surg. 1993;18:596–605
  5. Plate G, Einarsson E, Ohlin P, Jensen R, Qvarfordt P, Eklof B. Thrombectomy with temporary arteriovenous fistula: the treatment of choice in acute iliofemoral venous thrombosis. J Vasc Surg. 1984;1:867–876
  6. Plate G, Akesson H, Einarsson E, Ohlin P, Eklof B. Long-term results of venous thrombectomy combined with a temporary arterio-venous fistula. Eur J Vasc Surg. 1990;4:483–489
  7. Plate G, Eklof B, Norgren L, Ohlin P, Dahlstrom JA. Venous thrombectomy for iliofemoral vein thrombosis–10-year results of a prospective randomised study. Eur J Vasc Endovasc Surg. 1997;14:367–374
  8. Comerota AJ, Throm RC, Mathias SD, Haughton S, Mewissen M. Catheter-directed thrombolysis for iliofemoral deep venous thrombosis improves health-related quality of life. J Vasc Surg. 2000;32:130–137
  9. Elsharawy M, Elzayat E. Early results of thrombolysis vs anticoagulation in iliofemoral venous thrombosis (A randomised clinical trial). Eur J Vasc Endovasc Surg. 2002;24:209–214
  10. Kearon C, Kahn SR, Agnelli G, Goldhaber SZ, Raskob G, Comerota AJ. Antithrombotic therapy for venous thromboembolic disease: ACCP evidence-based clinical practice guidelines (8th ed). Chest. In press.
  11. Mewissen MW, Seabrook GR, Meissner MH, Cynamon J, Labropoulos N, Haughton SH. Catheter-directed thrombolysis for lower extremity deep venous thrombosis: report of a national multicenter registry. Radiology. 1999;211:39–49
  12. Bjarnason H, Kruse JR, Asinger DA, Nazarian GK, Dietz CA, Caldwell MD, et al. Iliofemoral deep venous thrombosis: safety and efficacy outcome during 5 years of catheter-directed thrombolytic therapy. J Vasc Interv Radiol. 1997;8:405–418
  13. Comerota AJ, Kagan SA. Catheter-directed thrombolysis for the treatment of acute iliofemoral deep venous thrombosis. Phlebology. 2001;15:149–155
  14. Vedantham S, Vesely TM, Parti N, Darcy M, Hovsepian DM, Picus D. Lower extremity venous thrombolysis with adjunctive mechanical thrombectomy. J Vasc Interv Radiol. 2002;13:1001–1008
  15. Kasirajan K, Gray B, Ouriel K. Percutaneous AngioJet thrombectomy in the management of extensive deep venous thrombosis. J Vasc Interv Radiol. 2001;12:179–185
  16. Bush RL, Lin PH, Bates JT, Mureebe L, Zhou W, Lumsden AB. Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility study. J Vasc Surg. 2004;40:965–970
  17. Lin PH, Zhou W, Dardik A, Mussa F, Kougias P, Hedayati N, et al. Catheter-direct thrombolysis versus pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis. Am J Surg. 2006;192:782–788
  18. O'Sullivan GJ, Lohan DG, Gough N, Cronin CG, Kee ST. Pharmacomechanical thrombectomy of acute deep vein thrombosis with the Trellis-8 isolated thrombolysis catheter. J Vasc Interv Radiol. 2007;18:715–724
  19. Hilleman DE, Razavi MK. Clinical and economic evaluation of the Trellis-8 infusion catheter for deep vein thrombosis. J Vasc Interv Radiol. 2008;19:377–383
  20. Hull RD, Marder VJ, Mah AF, Biel RK, Brant RF. Quantitative assessment of thrombus burden predicts the outcome of treatment for venous thrombosis: a systematic review. Am J Med. 2005;118:456–464
  21. Prandoni P, Lensing AW, Prins MH, Bernardi E, Marchiori A, Bagatella P, et al. Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med. 2002;137:955–960
  22. Agnelli G, Becattini C, Kirschstein T. Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis. Arch Intern Med. 2002;162:2537–2541
  23. Kakkar VV, Hoppenstead DA, Fareed J, Kadziola Z, Scully M, Nakov R, et al. Randomized trial of different regimens of heparins and in vivo thrombin generation in acute deep vein thrombosis. Blood. 2002;99:1965–1970
  24. Parikh S, Motarjeme A, McNamara T, Raabe R, Hagspiel K, Katzen BT, et al. Ultrasound accelerated thrombolysis for the treatment of deep venous thrombosis: initial clinical experience. J Vasc Interv Radiol. In press.
  25. Grunwald MR, Hofmann LV. Comparison of urokinase, alteplase, and reteplase for catheter-directed thrombolysis of deep venous thrombosis. J Vasc Interv Radiol. 2004;15:347–352
  26. Comerota AJ, Aldridge SC, Cohen G, Ball DS, Pliskin M, White JV. A strategy of aggressive regional therapy for acute iliofemoral venous thrombosis with contemporary venous thrombectomy or catheter-directed thrombolysis. J Vasc Surg. 1994;20:244–254
  27. Comerota AJ, Paolini D. Treatment of acute iliofemoral deep venous thrombosis: a strategy of thrombus removal. Eur J Vasc Endovasc Surg. 2007;33:351–360

 Competition of interest: none.

PII: S0741-5214(08)01148-8

doi: 10.1016/j.jvs.2008.07.013

Journal of Vascular Surgery
Volume 48, Issue 6 , Pages 1532-1537 , December 2008

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