Journal of Vascular Surgery
Volume 48, Issue 5 , Pages 1139-1145 , November 2008

Factors associated with stroke or death after carotid endarterectomy in Northern New England

Presented at the Twenty-First Annual Meeting of the Eastern Vascular Society, Baltimore, Md, Sep 27-29, 2007

Received 17 February 2008 ,Accepted 4 May 2008.

References 

  1. Musser DJ, Nicholas GG, Reed JF. Death and adverse cardiac events after carotid endarterectomy. J Vasc Surg. 1994;19:615–622
  2. Rothwell PM, Warlow CP. Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study (European Carotid Surgery Trialists' Collaborative Group). [see comment]. Lancet. 1999;353:2105–2110
  3. Tu JV, Wang H, Bowyer B, Green L, Fang J, Kucey D, et al. Risk factors for death or stroke after carotid endarterectomy: observations from the Ontario Carotid Endarterectomy Registry. [see comment] Stroke. 2003;34:2568–2573
  4. Sacco RL, Benjamin EJ, Broderick JP, Dyken M, Easton JD, Feinberg WM, et al. American Heart Association Prevention Conference (IV. Prevention and Rehabilitation of Stroke. Risk factors). Stroke. 1999;28:1507–1517
  5. Kakkos SK, Nicolaides A, Griffin M, Sabetai M, Dhanjil S, Thomas DJ, et al. Factors associated with mortality in patients with asymptomatic carotid stenosis: results from the ACSRS Study. Int Angiol. 2005;24:221–230
  6. Kresowik TF, Bratzler D, Karp HR, Hemann RA, Hendel ME, Grund SL, et al. Multistate utilization, processes, and outcomes of carotid endarterectomy. J Vasc Surg. 2001;33:227–234discussion 234-5.
  7. Goldstein LB. Extracranial carotid artery stenosis. Stroke. 2003;34:2767–2773
  8. Frawley JE, Hicks RG, Woodforth IJ. Risk factors for peri-operative stroke complicating carotid endarterectomy: selective analysis of a prospective audit of 1000 consecutive operations. Aust N Z J Surg. 2000;70:52–56
  9. Lindblad B, Persson NH, Takolander R, Bergqvist D. Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? (A double-blind, placebo-controlled randomized trial). Stroke. 1993;24:1125–1128
  10. Payne DA, Jones CI, Hayes PD, Naylor AR, Goodall AH. Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight. Stroke. 2007;38:2464–2469
  11. Payne DA, Jones CI, Hayes PD, Thompson MM, London NJ, Bell PR, et al. Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy. [see comment] Circulation. 2004;109:1476–1481
  12. Taylor DW, Barnett HJ, Haynes RB, Ferguson GG, Sackett DL, Thorpe KE, et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial (ASA and Carotid Endarterectomy (ACE) Trial Collaborators). [see comment] Lancet. 1999;353:2179–2184
  13. Halm EA, Lee C, Chassin MR. Is volume related to outcome in health care? (A systematic review and methodologic critique of the literature). [summary for patients in Ann Intern Med. 2002;137:I52; PMID: 12230383] Ann Intern Med. 2002;137:511–550
  14. Pine M, Jordan HS, Elixhauser A, Fry DE, Hoaglin DC, Jones B, et al. Enhancement of claims data to improve risk adjustment of hospital mortality. JAMA. 2007;297:71–76
  15. Teres D, Higgins TL. What if your hospital informatics department could provide a severity adjuster?. [comment] Crit Care Med. 2000;28:3570–3571
  16. El-Tamer MB, Ward BM, Schifftner T, Neumayer L, Khuri S, Henderson W. Morbidity and mortality following breast cancer surgery in women: national benchmarks for standards of care. [see comment] Ann Surg. 2007;245:665–671
  17. Brass EP, Hiatt WR. Review of mortality and cardiovascular event rates in patients enrolled in clinical trials for claudication therapies. Vasc Med. 2006;11:141–145
  18. Wyse RKH, Taylor KM. Using the STS and multinational cardiac surgical databases to establish risk-adjusted benchmarks for clinical outcomes. Heart Surg Forum. 2002;5:258–264
  19. Peterson ED, DeLong ER, Muhlbaier LH, Rosen AB, Buell HE, Kiefe CI, et al. Challenges in comparing risk-adjusted bypass surgery mortality results: results from the Cooperative Cardiovascular Project. J Am Coll Cardiol. 2000;36:2174–2184
  20. Cronenwett JL, Russell MT, Likosky DS, Eldrup-Jorgensen J, Stanley AC, Nolan BW, et al. A regional registry for quality assurance and improvement: the Vascular Study Group of Northern New England (VSG-NNE). J Vasc Surg. 2007;46:1093–1101
  21. Birkmeyer JD, Stukel TA, Siewers AE, Goodney PP, Wennberg DE, Lucas FL. Surgeon volume and operative mortality in the United States. [see comment] N Engl J Med. 2003;349:2117–2127
  22. Cowan JA, Dimick JB, Thompson BG, Stanley JC, Upchurch GR. Surgeon volume as an indicator of outcomes after carotid endarterectomy: an effect independent of specialty practice and hospital volume. [see comment] J Am Coll Surg. 2002;195:814–821
  23. Holt PJ, Poloniecki JD, Loftus IM, Thompson MM. Meta-analysis and systematic review of the relationship between hospital volume and outcome following carotid endarterectomy. Eur J Vasc Endovasc Surg. 2007;33:645–651
  24. Anonymous. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. [see comment]. JAMA 1421;273:1421-8.
  25. Ballotta E, Renon L, Da Giau G, Barbon B, Terranova O, Baracchini C. Octogenarians with contralateral carotid artery occlusion: a cohort at higher risk for carotid endarterectomy?. J Vasc Surg. 2003;39:1003–1008
  26. Tu JV, Hannan EL, Anderson GM, Wu K, Vranizan K, Popp AJ, et al. The fall and rise of carotid endarterectomy in the United States and Canada. N Engl J Med. 1998;339:1441–1447
  27. Eliasziw M, Streifler JY, Spence JD, Fox AJ, Hachinski VC, Barnett HJ. Prognosis for patients following a transient ischemic attack with and without a cerebral infarction on brain CT (North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group). Neurology. 1995;45:428–431
  28. Bhatti AF, Leon LR, Labropoulos N, Rubinas TL, Rodriguez H, Kalman PG, et al. Free-floating thrombus of the carotid artery: literature review and case reports. J Vasc Surg. 2007;45:199–205
  29. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis (North American Symptomatic Carotid Endarterectomy Trial Collaborators). [see comment] N Engl J Med. 1991;325:445–453
  30. Assadian A, Eidher U, Senekowitsch C, Rotter R, Löchli S, Hagmüller GW, et al. Antiplatelet therapy prior to carotid endarterectomy–still room for improvement. Vasa. 2006;35:96–100
  31. Cronenwett JL, Likosky DS, Russell MT, Eldrup-Jorgensen J, Stanley AC, Nolan BW, et al. A regional registry for quality assurance and improvement: the Vascular Study Group of Northern New England (VSGNNE). J Vasc Surg. 2007;46:1093–1101discussion 1101-2.
  32. O'Connor GT, Plume SK, Olmstead EM, Morton JR, Maloney CT, Nugent WC, et al. A regional prospective study of in-hospital mortality associated with coronary artery bypass grafting (The Northern New England Cardiovascular Disease Study Group). [see comment] JAMA. 1991;266:803–809
  33. Endarterectomy for asymptomatic carotid artery stenosis (Executive Committee for the Asymptomatic Carotid Atherosclerosis Study). JAMA. 1991;273:1421–1428
  34. Perler BA. The effect of statin medications on perioperative and long-term outcomes following carotid endarterectomy or stenting. Semin Vasc Surg. 2007;20:252–258
  35. McGirt MJ, Perler BA, Brooke BS, Woodworth GF, Coon A, Jain S, et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy. [see comment] J Vasc Surg Nov. 2005;42:829–836discussion 836-827.
  36. Kennedy J, Quan H, Buchan AM, Ghali WA, Feasby TE. Statins are associated with better outcomes after carotid endarterectomy in symptomatic patients. [see comment] Stroke. 2005;36:2072–2076

 This project was funded in part with federal funds from The Department of Health and Human Services Centers for Medicare & Medicaid Services (CMS) under Cooperative Agreement Award number 18-C-91674/1/01 awarded to the Trustees of Dartmouth College.

 Competition of interest: none.

PII: S0741-5214(08)00724-6

doi: 10.1016/j.jvs.2008.05.013

Journal of Vascular Surgery
Volume 48, Issue 5 , Pages 1139-1145 , November 2008

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