Endogenous heparin activity is decreased in peripheral arterial occlusive disease

Baseline (native) thromboelastography of a venous sample from control subjects. A, Current amplitude; Angle, acceleration of fibrin buildup and cross-linking (clot strengthening); CI, coagulation index (overall coagulation status); EPL, estimated percent lysis; G, clot firmness as shear elastic modulus; K, dynamics of clot formation; LY30, percent lysis at 30 minutes after maximum amplitude; LY60, percent lysis at 60 minutes after maximum amplitude; MA, maximum amplitude (ultimate clot strength); R, reaction time (time to initial fibrin formation).

Overall coagulability and peripheral ischemia.

Endogenous heparin-like activity in patients with peripheral arterial occlusive disease. ΔR is the change in latent period between when the sample is recalcified and initial fibrin formation.

Severity of peripheral arterial occlusive disease and endogenous heparin-like activity. ΔR is the change in latent period between when the sample is recalcified and initial fibrin formation.