Journal of Vascular Surgery
Volume 47, Issue 3 , Pages 566-570 , March 2008

Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism

  • Stefan Mustafa, MD, PhD

      Affiliations

    • Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    • ,
  • Ansgar Weltermann, MD

      Affiliations

    • Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    • ,
  • Robert Fritsche, MD, ScM

      Affiliations

    • Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    • Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
    • ,
  • Claudia Marsik, MD

      Affiliations

    • Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    • Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
    • ,
  • Oswald Wagner, MD

      Affiliations

    • Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    • ,
  • Paul A. Kyrle, MD

      Affiliations

    • Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    • ,
  • Sabine Eichinger, MD

      Affiliations

    • Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationCorrespondence: Sabine Eichinger, Department of Internal Medicine I, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Received 18 April 2007 ,Accepted 26 September 2007.

References 

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  5. Fujita T, Toda K, Karimova A, Yan SF, Naka Y, Yet SF, et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 2001;7:598–604
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  12. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, et al. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet. 2002;111:1–8
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  14. Ono K, Goto Y, Takagi S, Baba S, Tago N, Nonogi H, et al. A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Atherosclerosis. 2004;173:315–319
  15. Schillinger M, Exner M, Minar E, Mlekusch W, Mullner M, Mannhalter C, et al. Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. J Am Coll Cardiol. 2004;43:950–957
  16. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet. 2000;66:187–195
  17. Kyrle PA, Minar E, Bialonczyk C, Hirschl M, Weltermann A, Eichinger S. The risk of recurrent venous thromboembolism in men and women. N Engl J Med. 2004;350:2558–2563
  18. Cooper DN, Nussbaum RL, Krawczak M. Proposed guidelines for papers describing DNA polymorphism-disease associations. Hum Genet. 2002;110:207–208
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  20. Ferroni P, Basili S, Falco A, Davi G. Oxidant stress and platelet activation in hypercholesterolemia. Antioxid Redox Signal. 2004;6:747–756
  21. Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, Kobayashi S, et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood. 2003;102:1619–1621
  22. Cambien B, Wagner DD. A new role in hemostasis for the adhesion receptor P-selectin. Trends Mol Med. 2004;10:179–186
  23. Kyrle PA, Hron G, Eichinger S, Wagner O. Circulating P-selectin and the risk of recurrent venous thromboembolism. Thromb Haemost. 2007;97:880–883

 Competition of interest: none.

PII: S0741-5214(07)01549-2

doi: 10.1016/j.jvs.2007.09.060

Journal of Vascular Surgery
Volume 47, Issue 3 , Pages 566-570 , March 2008

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