Journal of Vascular Surgery
Volume 46, Issue 4 , Pages 676-681 , October 2007

Anemia is associated with abdominal aortic aneurysm (AAA) size and decreased long-term survival after endovascular AAA repair

  • Nicolas Diehm, MD

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Interventional Radiology, Miami, Fla
    • Swiss Cardiovascular Center, Division of Clinical and Interventional Angiology and Vascular Research, Inselspital, University Hospital, Bern, Switzerland
  • ,
  • James F. Benenati, MD

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Interventional Radiology, Miami, Fla
    • Corresponding Author InformationCorrespondence: James F. Benenati, MD, Baptist Cardiac and Vascular Institute, 8900 North Kendall Drive, Miami, FL 33176.
  • ,
  • Gary J. Becker, MD

      Affiliations

    • Department of Radiology, Vascular & Interventional Section, University of Arizona College of Medicine, Phoenix, Ariz
  • ,
  • Ramon Quesada, MD

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Clinical and Interventional Cardiology, Miami, Fla
  • ,
  • Athanassios I. Tsoukas, MD

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Vascular Surgery, Miami, Fla.
  • ,
  • Barry T. Katzen, MD

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Interventional Radiology, Miami, Fla
  • ,
  • Margaret Kovacs, EdD, RNC

      Affiliations

    • Baptist Cardiac and Vascular Institute, Division of Interventional Radiology, Miami, Fla

Received 24 April 2007 ,Accepted 10 June 2007.

References 

  1. Szilagyi DE, Smith RF, DeRusso FJ, Elliott JP, Sherrin FW. Contribution of abdominal aortic aneurysmectomy to prolongation of life. Ann Surg. 1966;164:678–699
  2. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15:1145–1151
  3. Diehm N, Schmidli J, Dai-Do D, Baumgartner I. Current evidence and prospects for medical treatment of abdominal aortic aneurysms. VASA. 2005;34:217–223
  4. Greenhalgh RM, Brown LC, Kwong GP, Powell JT, Thompson SG. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomized controlled trial. Lancet. 2004;364:843–848
  5. Prinssen M, Verhoeven EL, Buth J, Cuypers PW, van Sambeek MR, Balm R, et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med. 2004;351:1607–1618
  6. Arko FR, Lee WA, Hill BB, Olcott Ct, Dalman RL, Harris EJ, et al. Aneurysm-related death: primary endpoint analysis for comparison of open and endovascular repair. J Vasc Surg. 2002;36:297–304
  7. Zarins CK, Crabtree T, Bloch DA, Arko FR, Ouriel K, White RA. Endovascular aneurysm repair at 5 years: Does aneurysm diameter predict outcome?. J Vasc Surg. 2006;44:920–929
  8. Brewster DC, Jones JE, Chung TK, Lamuraglia GM, Kwolek CJ, Watkins MT, et al. Long-term outcomes after endovascular abdominal aortic aneurysm repair: the first decade. Ann Surg. 2006;244:426–438
  9. Sicard GA, Zwolak RM, Sidawy AN, White RA, Siami FS. Endovascular abdominal aortic aneurysm repair: long-term outcome measures in patients at high-risk for open surgery. J Vasc Surg. 2006;44:229–236
  10. Jones KG, Brull DJ, Brown LC, Sian M, Greenhalgh RM, Humphries SE, et al. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation. 2001;103:2260–2265
  11. Vainas T, Lubbers T, Stassen FR, Herngreen SB, van Dieijen-Visser MP, Bruggeman CA, et al. Serum C-reactive protein level is associated with abdominal aortic aneurysm size and may be produced by aneurysmal tissue. Circulation. 2003;107:1103–1105
  12. Rohde LE, Arroyo LH, Rifai N, Creager MA, Libby P, Ridker PM, et al. Plasma concentrations of interleukin-6 and abdominal aortic diameter among subjects without aortic dilatation. Arterioscler Thromb Vasc Biol. 1999;19:1695–1699
  13. Norman P, Spencer CA, Lawrence-Brown MM, Jamrozik K. C-reactive protein levels and the expansion of screen-detected abdominal aortic aneurysms in men. Circulation. 2004;110:862–866
  14. Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR trial 2): randomised controlled trial. Lancet. 2005;365:2187–2192
  15. Lloyd GM, Newton JD, Norwood MG, Franks SC, Bown MJ, Sayers RD. Patients with abdominal aortic aneurysm: are we missing the opportunity for cardiovascular risk reduction?. J Vasc Surg. 2004;40:691–697
  16. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  17. Schouten O, Kok NF, Hoedt MT, van Laanen JH, Poldermans D. The influence of aneurysm size on perioperative cardiac outcome in elective open infrarenal aortic aneurysm repair. J Vasc Surg. 2006;44:435–441
  18. Brady AR, Fowkes FG, Thompson SG, Powell JT. Aortic aneurysm diameter and risk of cardiovascular mortality. Arterioscler Thromb Vasc Biol. 2001;21:1203–1207
  19. Peppelenbosch N, Buth J, Harris PL, van Marrewijk C, Fransen G. Diameter of abdominal aortic aneurysm and outcome of endovascular aneurysm repair: does size matter? A report from EUROSTAR. J Vasc Surg. 2004;39:288–297
  20. Schouten O, van Waning VH, Kertai MD, Feringa HH, Bax JJ, Boersma E, et al. Perioperative and long-term cardiovascular outcomes in patients undergoing endovascular treatment compared with open vascular surgery for abdominal aortic aneurysm or iliaco-femoro-popliteal bypass. Am J Cardiol. 2005;96:861–866
  21. Stenvinkel P. The role of inflammation in the anaemia of end-stage renal disease. Nephrol Dial Transplant. 2001;16:36–40
  22. Nissenson AR, Goodnough LT, Dubois RW. Anemia: not just an innocent bystander?. Arch Intern Med. 2003;163:1400–1404
  23. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
  24. McClellan WM, Flanders WD, Langston RD, Jurkovitz C, Presley R. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: a population-based study. J Am Soc Nephrol. 2002;13:1928–1936
  25. Langston RD, Presley R, Flanders WD, McClellan WM. Renal insufficiency and anemia are independent risk factors for death among patients with acute myocardial infarction. Kidney Int. 2003;64:1398–1405
  26. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new-onset heart failure. Circulation. 2003;107:223–225
  27. Matzner Y, Levy S, Grossowicz N, Izak G, Hershko C. Prevalence and causes of anemia in elderly hospitalized patients. Gerontology. 1979;25:113–119
  28. Salive ME, Cornoni-Huntley J, Guralnik JM, Phillips CL, Wallace RB, Ostfeld AM, et al. Anemia and hemoglobin levels in older persons: relationship with age, gender, and health status. J Am Geriatr Soc. 1992;40:489–496
  29. Weiss G. Pathogenesis and treatment of anaemia of chronic disease. Blood Rev. 2002;16:87–96
  30. Newman KM, Jean-Claude J, Li H, Ramey WG, Tilson MD. Cytokines that activate proteolysis are increased in abdominal aortic aneurysms. Circulation. 1994;90:224–227
  31. Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991;5:491–499
  32. Katzen BT, Dake MD, MacLean AA, Wang DS. Endovascular repair of abdominal and thoracic aortic aneurysms. Circulation. 2005;112:1663–1675
  33. World Health Organization. Nutritional anemias: Report of a WHO Scientific Group. 1968;Geneva, Switzerland
  34. Chaikof EL, Blankensteijn JD, Harris PL, White GH, Zarins CK, Bernhard VM, et al. Reporting standards for endovascular aortic aneurysm repair. J Vasc Surg. 2002;35:1048–1060
  35. Suggested standards for reports dealing with lower extremity ischemia (Prepared by the Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery/North American Chapter, International Society for Cardiovascular Surgery). J Vasc Surg. 1986;4:80–94
  36. Moore WS, Matsumura JS, Makaroun MS, Katzen BT, Deaton DH, Decker M, et al. Five-year interim comparison of the Guidant bifurcated endograft with open repair of abdominal aortic aneurysm. J Vasc Surg. 2003;38:46–55
  37. Faries PL, Brener BJ, Connelly TL, Katzen BT, Briggs VL, Burks JA, et al. A multicenter experience with the Talent endovascular graft for the treatment of abdominal aortic aneurysms. J Vasc Surg. 2002;35:1123–1128
  38. Najibi S, Steinberg J, Katzen BT, Zemel G, Lin PH, Weiss VJ, et al. Detection of isolated hook fractures 36 months after implantation of the Ancure endograft: a cautionary note. J Vasc Surg. 2001;34:353–356
  39. Matsumura JS, Katzen BT, Hollier LH, Dake MD. Update on the bifurcated EXCLUDER endoprosthesis: phase I results. J Vasc Surg. 2001;33:S150–S153
  40. Jongen-Lavrencic M, Peeters HR, Wognum A, Vreugdenhil G, Breedveld FC, Swaak AJ. Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease. J Rheumatol. 1997;24:1504–1509
  41. Newman KM, Jean-Claude J, Li H, Ramey WG, Tilson MD. Cytokines that activate proteolysis are increased in abdominal aortic aneurysms. Circulation. 1994;90:II224–II227
  42. Shteinberg D, Halak M, Shapiro S, Kinarty A, Sobol E, Lahat N, et al. Abdominal aortic aneurysm and aortic occlusive disease: a comparison of risk factors and inflammatory response. Eur J Vasc Endovasc Surg. 2000;20:462–465
  43. Kragsterman B, Bjorck M, Lindback J, Bergqvist D, Parsson H. Long-term survival after carotid endarterectomy for asymptomatic stenosis. Stroke. 2006;37:2886–2891
  44. van Wijk I, Kappelle LJ, van Gijn J, Koudstaal PJ, Franke CL, Vermeulen M, et al. Long-term survival and vascular event risk after transient ischemic attack or minor ischemic stroke: a cohort study. Lancet. 2005;365:2098–2104
  45. Brenner H, Stegmaier C, Ziegler H. Long-term survival of cancer patients in Germany achieved by the beginning of the third millenium. Ann Oncol. 2005;16:981–986
  46. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007;45:S5–S67
  47. Ganz T. Molecular control of iron transport. J Am Soc Nephrol. 2007;18:394–400
  48. Konijn AM, Carmel N, Levy R, Hershko C. Ferritin synthesis in inflammation (II. Mechanism of increased ferritin synthesis). Br J Haematol. 1981;49:361–370
  49. Kertai MD, Boersma E, Westerhout CM, van Domburg R, Klein J, Bax JJ, et al. Association between long-term statin use and mortality after successful abdominal aortic aneurysm surgery. Am J Med. 2004;116:96–103
  50. Leurs LJ, Visser P, Laheij RJ, Buth J, Harris PL, Blankensteijn JD. Statin use is associated with reduced all-cause mortality after endovascular abdominal aortic aneurysm repair. Vascular. 2006;14:1–8
  51. Nagashima H, Aoka Y, Sakomura Y, Sakuta A, Aomi S, Ishizuka N, et al. A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J Vasc Surg. 2002;6:158–163
  52. Steinmetz EF, Buckley C, Shames ML, Ennis TL, Vanvickle-Chavez SJ, Mao D, et al. Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice. Ann Surg. 2005;241:92–101
  53. Wilson WR, Evans J, Bell PR, Thompson MM. HMG-CoA reductase inhibitors (statins) decrease MMP-3 and MMP-9 concentrations in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2005;3:259–262
  54. Schrier S. Anemia of chronic disease (anemia of inflammation). In: www.uptodate.com; accessed March 2007.

 Competition of interest: none.

PII: S0741-5214(07)00998-6

doi: 10.1016/j.jvs.2007.06.027

Journal of Vascular Surgery
Volume 46, Issue 4 , Pages 676-681 , October 2007