Journal of Vascular Surgery
Volume 46, Issue 3 , Pages 449-454 , September 2007

Fibrinogen and high-sensitive C-reactive protein as serologic predictors for perioperative cerebral microembolic lesions after carotid endarterectomy

  • Peter Heider, MD

      Affiliations

    • Department of Vascular Surgery, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
    • Corresponding Author InformationReprint requests: Dr Peter Heider, Rechts der Isar Medical Center, Technical University of Munich, Ismaninger Str 22, D-81675 Munich, Germany.
  • ,
  • Holger Poppert, MD

      Affiliations

    • Department of Neurology, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
  • ,
  • Oliver Wolf, MD

      Affiliations

    • Department of Vascular Surgery, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
  • ,
  • Thomas Liebig, MD

      Affiliations

    • Department of Neuroradiology, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
  • ,
  • Jaroslav Pelisek, PhD

      Affiliations

    • Department of Vascular Surgery, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
  • ,
  • Tibor Schuster, PhD

      Affiliations

    • Institute of Epidemiology and Medical Statistics, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany.
  • ,
  • Hans H. Eckstein, MD

      Affiliations

    • Department of Vascular Surgery, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany

Received 23 March 2007 ,Accepted 14 May 2007.

References 

  1. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis (North American Symptomatic Carotid Endarterectomy Trial Collaborators). N Engl J Med. 1991;325:445–453
  2. Wolf O, Heider P, Heinz M, Poppert H, Schmidt-Thieme T, Sander D, et al. Frequency, clinical significance and course of cerebral ischemic events after carotid endarterectomy evaluated by serial diffusion weighted imaging. Eur J Vasc Endovasc Surg. 2004;27:167–171
  3. Bots ML, Elwood PC, Salonen JT, de Freire C, Sivenius J, Di Carlo A, et al. Level of fibrinogen and risk of fatal and non-fatal stroke (EUROSTROKE: a collaborative study among research centres in Europe). J Epidemiol Community Health. 2002;56:i14–i18
  4. Kofoed SC, Wittrup HH, Sillesen H, Nordestgaard BG. Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not echolucent, rupture-prone carotid plaques: the Copenhagen City Heart Study. Eur Heart J. 2003;24:567–576
  5. Dosa E, Rugonfalvi-Kiss S, Prohaszka Z, Szabo A, Karadi I, Selmeci L, et al. Marked decrease in the levels of two inflammatory markers, hs-C-reactive protein and fibrinogen in patients with severe carotid atherosclerosis after eversion carotid endarterectomy. Inflamm Res. 2004;53:631–635
  6. Maresca G, Di Blasio A, Marchioli R, Di Minno G. Measuring plasma fibrinogen to predict stroke and myocardial infarction: an update. Arterioscler Thromb Vasc Biol. 1999;19:1368–1377
  7. Bini A, Kudryk BJ. Fibrin and its derivatives in the normal and diseased vessel wall. Ann N Y Acad Sci. 1992;667:112–126
  8. Mauriello A, Sangiorgi G, Palmieri G, Virmani R, Holmes DR, Schwartz RS, et al. Hyperfibrinogenemia is associated with specific histocytological composition and complications of atherosclerotic carotid plaques in patients affected by transient ischemic attacks. Circulation. 2000;101:744–750
  9. Pai JK, Curhan GC, Cannuscio CC, Rifai N, Ridker PM, Rimm EB. Stability of novel plasma markers associated with cardiovascular disease: processing within 36 hours of specimen collection. Clin Chem. 2002;48:1781–1784
  10. Kondo K, Kitagawa K, Nagai Y, Yamagami H, Hashimoto H, Hougaku H, et al. Associations of soluble intercellular adhesion molecule-1 with carotid atherosclerosis progression. Atherosclerosis. 2005;179:155–160
  11. Rerkasem K, Shearman CP, Williams JA, Morris GE, Phillips MJ, Calder PC, et al. C-reactive protein is elevated in symptomatic compared with asymptomatic patients with carotid artery disease. Eur J Vasc Endovasc Surg. 2002;23:505–509
  12. Choi H, Cho DH, Shin HH, Park JB. Association of high sensitivity C-reactive protein with coronary heart disease prediction, but not with carotid atherosclerosis, in patients with hypertension. Circ J. 2004;68:297–303
  13. Jahn J, Hellmann I, Maass M, Giannitsis E, Dalhoff K, Katus HA. Time-dependent changes of hs-CRP serum concentration in patients with non-ST elevation acute coronary syndrome. Herz. 2004;29:795–801
  14. Alvarez GB, Ruiz C, Chacon P, Sabin JA, Matas M. High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque. J Vasc Surg. 2003;38:1018–1024
  15. Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation. 2001;103:1194–1197
  16. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102:2165–2168
  17. Hashimoto H, Kitagawa K, Hougaku H, Shimizu Y, Sakaguchi M, Nagai Y, et al. C-reactive protein is an independent predictor of the rate of increase in early carotid atherosclerosis. Circulation. 2001;104:63–67
  18. Tanne D, Benderly M, Goldbourt U, Haim M, Tenenbaum A, Fisman EZ, et al. C-reactive protein as a predictor of incident ischemic stroke among patients with preexisting cardiovascular disease. Stroke. 2006;37:1720–1724
  19. Ma J, Hennekens CH, Ridker PM, Stampfer MJ. A prospective study of fibrinogen and risk of myocardial infarction in the Physicians’ Health Study. J Am Coll Cardiol. 1999;33:1347–1352
  20. Coppola G, Rizzo M, Abrignani MG, Corrado E, Di Girolamo A, Braschi A, et al. Fibrinogen as a predictor of mortality after acute myocardial infarction: a forty-two-month follow-up study. Ital Heart J. 2005;6:315–322
  21. Gonzalez-Conejero R, Fernandez-Cadenas I, Iniesta JA, Marti-Fabregas J, Obach V, Alvarez-Sabin J, et al. Role of fibrinogen levels and factor XIII V34L polymorphism in thrombolytic therapy in stroke patients. Stroke. 2006;37:2288–2293
  22. Di Napoli M, Papa F, Bocola V. Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Stroke. 2001;32:133–138
  23. Ross R. Atherosclerosis–an inflammatory disease. N Engl J Med. 1999;340:115–126
  24. Levenson J, Giral P, Razavian M, Gariepy J, Simon A. Fibrinogen and silent atherosclerosis in subjects with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 1995;15:1263–1268
  25. Sethi AA, Tybjaerg-Hansen A, Gronholdt ML, Steffensen R, Schnohr P, Nordestgaard BG. Angiotensinogen mutations and risk for ischemic heart disease, myocardial infarction, and ischemic cerebrovascular disease (Six case-control studies from the Copenhagen City Heart Study). Ann Intern Med. 2001;134:941–954

 Competition of interest: none.

 Financial support for this study was provided by the Commission of Clinical Research, Rechts der Isar Medical Center, Technical University of Munich (Kommission für Klinische Forschung, KKF-Nr.: 8744652).

PII: S0741-5214(07)00963-9

doi: 10.1016/j.jvs.2007.05.035

Journal of Vascular Surgery
Volume 46, Issue 3 , Pages 449-454 , September 2007