Journal of Vascular Surgery
Volume 45, Issue 4 , Pages 701-705 , April 2007

Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: A retrospective case–control study

  • Anita C. Peeters, MD

      Affiliations

    • Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Bart A. van Landeghem, PhD

      Affiliations

    • Department of Clinical Chemistry and Haematology, St. Elisabeth Hospital, Tilburg, The Netherlands
  • ,
  • Sietze J. Graafsma, PhD, MD

      Affiliations

    • Department of Internal Medicine, TweeSteden Hospital, Tilburg, The Netherlands
  • ,
  • Steef E. Kranendonk, PhD, MD

      Affiliations

    • Department of Surgery, TweeSteden Hospital, Tilburg, The Netherlands.
  • ,
  • Ad R. Hermus, PhD, MD

      Affiliations

    • Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Henk J. Blom, PhD

      Affiliations

    • Department of Paediatrics, Laboratory of Paediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Martin den Heijer, PhD, MD

      Affiliations

    • Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationReprint requests: Martin den Heijer, MD, PhD, Department of Endocrinology (471), Radboud University Nijmegen Medical Centre, PO-Box 9101, 6500 HB Nijmegen, The Netherlands.

Received 16 October 2006 ,Accepted 8 December 2006.

References 

  1. Van der Vliet JA, Boll APM. Abdominal aortic aneurysm. Lancet. 1997;349:863–866
  2. Reed D, Reed C, Stemmermann G, Hayashi T. Are aortic aneurysms caused by atherosclerosis?. Circulation. 1992;85:205–211
  3. Kadoglou NP, Liapis CD. Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms. Curr Med Res Opin. 2004;20:419–432
  4. Sakalihasan N, Limet R, Defawe OD. Abdominal aortic aneurysm. Lancet. 2005;365:1577–1589
  5. Homocysteine studies collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015–2022
  6. Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost. 2005;3:292–299
  7. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325:1202
  8. Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354:1578–1588
  9. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567–1577
  10. Brunelli T, Prisco D, Fedi S, Rogolino A, Farsi A, Marcucci R, et al. High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. J Vasc Surg. 2000;32:531–536
  11. Spark JI, Laws P, Fitridge R. The incidence of hyperhomocysteinaemia in vascular patients. Eur J Vasc Endocvasc Surg. 2003;26:558–561
  12. Warsi AA, Davies B, Morris-Stiff G, Hullin D, Lewis MH. Abdominal aortic aneurysm and its correlation to plasma homocysteine, and vitamins. Eur J Vasc Endovasc Surg. 2004;27:75–79
  13. Sofi F, Marcucci R, Giusti B, Pratesi G, Lari B, Sestini I, et al. High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-I are present in patients with abdominal aortic aneurysm. Thromb Haemost. 2005;94:1094–1098
  14. Zweers MC, Peeters ACTM, Graafsma S, Kranendonk S, van der Vliet JA, den Heijer M, et al. Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X. Circulation. 2006;113:1702–1707
  15. den Heijer M, Bos GMJ, Brouwer IA, Gerrits WWBJ, Blom HJ. Variability of the methionine loading test: no effect of a low protein diet. Ann Clin Biochem. 1996;33:551–554
  16. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422:43–52
  17. Ubbink JB, Serfontein WJ, De Villiers LS. Stability of pyridoxal-5-phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional status. J Chromatogr. 1985;342:277–284
  18. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. Identification of a candidate genetic risk factor for cardiovascular disease: A common mutation at the methylenetetrahydrofolate reductase locus. Nat Genet. 1995;10:111–113
  19. Kluytmans LAJ, van den Heuvel LPWJ, Boers GHJ, Frosst P, Stevens EMB, van Oost BA, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996;58:35–41
  20. Keijzer MBA, Verhoef P, Borm GF, Blom HJ, den Heijer M. No added value of the methionine loading test in assessment for venous thrombosis and cardiovascular disease risk. Thromb Haemost. 2006;95:380–385
  21. Smith GD, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?. Int J Epidemiol. 2003;32:1–22
  22. Robinson K, Arheart K, Refsum H, Brattström L, Boers GH, Ueland P, et al. Low circulating folate and vitamin B6 concentrations (Risk factors for stroke, peripheral vascular disease, and coronary artery disease). Circulation. 1998;97:437–443
  23. Friso S, Girelli D, Martinelli N, Olivieri O, Lotto V, Bozzini C, et al. Low plasma vitamin B6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 2004;79:992–998
  24. Carrington MJ, Bird TA, Levene CI. The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal (Effect on collagen cross-linking in the chick embryo). Biochem J. 1984;221:837–843
  25. Levene CI, Sharman DF, Callingham BA. Inhibition of chick embryo lysyl oxidase by various lathyrogens and the antagonistic effect of pyridoxal. Int J Exp Pathol. 1992;73:613–624
  26. Massé PG, Rimnac CM, Yamauchi M, Coburn SP, Rucker RB, Howell DS, et al. Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone. 1996;18:567–574
  27. Massé PG, Yamauchi M, Mahuren JD, Coburn SP, Muniz OE, Howell DS. Connective tissue integrity is lost in vitamin B6 deficient chicks. J Nutr. 1995;125:26–34

 This work was supported by the “Stichting Voorziening voor Wetenschappelijk onderzoek,” Tilburg, The Netherlands.

 Competition of interest: none.

PII: S0741-5214(06)02255-5

doi: 10.1016/j.jvs.2006.12.019

Journal of Vascular Surgery
Volume 45, Issue 4 , Pages 701-705 , April 2007