Journal of Vascular Surgery
Volume 44, Issue 4 , Pages 732-739 , October 2006

Autologous bone-marrow mononuclear cell implantation for patients with Rutherford grade II-III thromboangiitis obliterans

  • Serkan Durdu, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara, Turkey
    • ,
  • Ahmet Ruchan Akar, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara, Turkey
    • Corresponding Author InformationReprint requests: Ruchan Akar, MD, FRCS CTh, Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Dikimevi, Ankara 06340 Turkey.
    • ,
  • Mutlu Arat, MD

      Affiliations

    • Department of Haematology, Cebeci Campus, University School of Medicine, Ankara, Turkey
    • ,
  • Tanzer Sancak, MD

      Affiliations

    • Department of Radiology, Ibni Sina Hospital, Ankara University School of Medicine, Ankara, Turkey.
    • ,
  • Neyyir Tuncay Eren, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara, Turkey
    • ,
  • Umit Ozyurda, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara, Turkey

Received 24 February 2006 ,Accepted 25 June 2006.

References 

  1. Olin JW . Thromboangiitis obliterans (Buerger’s disease) . N Engl J Med . 2000;343:864–869
  2. Roncon-Albuquerque R , Serrao P , Vale-Pereira R , Costa-Lima J , Roncon-Albuquerque R . Plasma catecholamines in Buerger’s disease: effects of cigarette smoking and surgical sympathectomy . Eur J Vasc Endovasc Surg . 2002;24:338–343
  3. Akar AR , Durdu S , Corapcioglu T , Ozyurda U . Regenerative medicine for cardiovascular disorders (New milestones: adult stem cells) . Artif Organs . 2006;30:213–232
  4. Asahara T , Murohara T , Sullivan A , Silver M , van der ZR , Li T , et al.   Isolation of putative progenitor endothelial cells for angiogenesis . Science . 1997;275:964–967
  5. Hristov M , Erl W , Weber PC . Endothelial progenitor cells: mobilization, differentiation, and homing . Arterioscler Thromb Vasc Biol . 2003;23:1185–1189
  6. Rafii S , Lyden D . Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration . Nat Med . 2003;9:702–712
  7. Asahara T , Kawamoto A . Endothelial progenitor cells for postnatal vasculogenesis . Am J Physiol Cell Physiol . 2004;287:C572–C579
  8. Isner JM , Asahara T . Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization . J Clin Invest . 1999;103:1231–1236
  9. Tateishi-Yuyama E , Matsubara H , Murohara T , Ikeda U , Shintani S , Masaki H , et al.   Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial . Lancet . 2002;360:427–435
  10. Higashi Y , Kimura M , Hara K , Noma K , Jitsuiki D , Nakagawa K , et al.   Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia . Circulation . 2004;109:1215–1218
  11. Saigawa T , Kato K , Ozawa T , Toba K , Makiyama Y , Minagawa S , et al.   Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells . Circ J . 2004;68:1189–1193
  12. Huang P , Li S , Han M , Xiao Z , Yang R , Han ZC . Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes . Diabetes Care . 2005;28:2155–2160
  13. Huang PP , Li SZ , Han MZ , Xiao ZJ , Yang RC , Qiu LG , et al.   Autologous transplantation of peripheral blood stem cells as an effective therapeutic approach for severe arteriosclerosis obliterans of lower extremities . Thromb Haemost . 2004;91:606–609
  14. Ishida A , Ohya Y , Sakuda H , Ohshiro K , Higashiuesato Y , Nakaema M , et al.   Autologous peripheral blood mononuclear cell implantation for patients with peripheral arterial disease improves limb ischemia . Circ J . 2005;69:1260–1265
  15. Kawamura A , Horie T , Tsuda I , Ikeda A , Egawa H , Imamura E , et al.   Prevention of limb amputation in patients with limbs ulcers by autologous peripheral blood mononuclear cell implantation . Ther Apher Dial . 2005;9:59–63
  16. Rutherford RB , Baker JD , Ernst C , Johnston KW , Porter JM , Ahn S , et al.   Recommended standards for reports dealing with lower extremity ischemia: revised version . J Vasc Surg . 1997;26:517–538
  17. Shionoya S . Diagnostic criteria of Buerger’s disease . Int J Cardiol . 1998;66:S243–S245
  18. Riebe D , Patterson RB , Braun CM . Comparison of two progressive treadmill tests in patients with peripheral arterial disease . Vasc Med . 2001;6:215–221
  19. Morgan MB , Crayford T , Murrin B , Fraser SC . Developing the Vascular Quality of Life Questionnaire: a new disease-specific quality of life measure for use in lower limb ischemia . J Vasc Surg . 2001;33:679–687
  20. Arslan O , Arat M , Ciftci A , Ayyildiz E , Ilhan O . Depletion of donors erythrocytes using cell separator in major ABO mismatched allogeneic bone marrow transplantation . Blood . 2000;96:5152
  21. Akar AR , Durdu S , Arikbuka M , Arat M , Soydan E , Arslan O , et al.   Implantation of autologous bone marrow mononuclear cells for Buerger’s disease with retractable limb ischaemia . Bone Marrow Transplant . 2005;35:S76
  22. Chu VF , Giaid A , Kuang JQ , McGinn AN , Li CM , Pelletier MP , et al.   Thoracic Surgery Directors Association Award (Angiogenesis in transmyocardial revascularization: comparison of laser versus mechanical punctures) . Ann Thorac Surg . 1999;68:301–307
  23. Reyes M , Dudek A , Jahagirdar B , Koodie L , Marker PH , Verfaillie CM . Origin of endothelial progenitors in human postnatal bone marrow . J Clin Invest . 2002;109:337–346
  24. Kalka C , Masuda H , Takahashi T , Kalka-Moll WM , Silver M , Kearney M , et al.   Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization . Proc Natl Acad Sci U S A . 2000;97:3422–3427
  25. Kinnaird T , Stabile E , Burnett MS , Epstein SE . Bone-marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences . Circ Res . 2004;95:354–363
  26. Epstein SE , Fuchs S , Zhou YF , Baffour R , Kornowski R . Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards . Cardiovasc Res . 2001;49:532–542
  27. Rajagopalan S , Mohler ER , Lederman RJ , Mendelsohn FO , Saucedo JF , Goldman CK , et al.   Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication . Circulation . 2003;108:1933–1938
  28. Esato K , Hamano K , Li TS , Furutani A , Seyama A , Takenaka H , et al.   Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease . Cell Transplant . 2002;11:747–752
  29. Akar AR , Durdu S , Arat M , Eren NT , Arslan O , Corapcioglu T , et al.   Therapeutic angiogenesis by autologous transplantation of bone-marrow mononuclear cells for Buerger’s patients with retractable limb ischaemia (Preliminary results) . Turkish J Haematology . 2004;21:13–21
  30. Olin JW , Young JR , Graor RA , Ruschhaupt WF , Bartholomew JR . The changing clinical spectrum of thromboangiitis obliterans (Buerger’s disease) . Circulation . 1990;82:IV3–IV8
  31. Cooper LT , Tse TS , Mikhail MA , McBane RD , Stanson AW , Ballman KV . Long-term survival and amputation risk in thrombangiitis abliterans (Buerger’s disease) . J Am Coll Cardiol . 2004;44:2410–2411
  32. Ohta T , Ishioashi H , Hosaka M , Sugimoto I . Clinical and social consequences of Buerger disease . J Vasc Surg . 2004;39:176–180
  33. Takemoto M , Liao JK . Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors . Arterioscler Thromb Vasc Biol . 2001;21:1712–1719
  34. Takeshita S , Isshiki T , Mori H , Tanaka E , Eto K , Miyazawa Y , et al.   Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischemia . Circulation . 1997;95:805–808

 This work was supported by the Biotechnology Institute Research Fund and Ankara University School of Medicine Research Council, Turkey. Dr Arat has been supported by the Turkish Academy of Sciences, in the framework of the Young Scientist Award Program (EA-TUBA-GEBIP/2004-1-1).Competition of interest: none.

PII: S0741-5214(06)01142-6

doi: 10.1016/j.jvs.2006.06.023

Journal of Vascular Surgery
Volume 44, Issue 4 , Pages 732-739 , October 2006

Article Tools

* Image Usage & Resolution