Journal of Vascular Surgery
Volume 33, Issue 4 , Pages 733-738 , April 2001

Histopathologic analysis of endovascular stent grafts from patients with aortic aneurysms: Does healing occur?

Presented at the Twenty-eighth Annual Symposium of the Society for Clinical Vascular Surgery, Rancho Mirage, Calif, Mar 15-19, 2000.

Received 30 March 2000 ,Accepted 22 November 2000.

References 

  1. Berger K, Sauvage LR, Rao AM, Wood SJ. Healing of arterial prostheses in man: its incompleteness. Ann Surg. 1972;175:118–127
  2. Ohki T, Marin ML, Veith FJ, Yuan JG, Ohki M, Soundararajan K, et al.  Anastomotic intimal hyperplasia: a comparison between conventional and endovascular stent graft techniques. J Surg Res. 1997;69:255–267
  3. Edwards WH, Mulherin JL. The role of graft material in femorotibial bypass grafts. Ann Surg. 1980;191:721–726
  4. Echave V, Koornick AR, Haimov M, Jacobson JH. Intimal hyperplasia as a complication of the use of the polytetrafluorethylene graft for femoral-popliteal bypass. Surgery. 1979;86:791–798
  5. Ombrellaro MP, Stevens SL, Kerstetter K, Freeman MB, Goldman MH. Healing characteristics of intraarterial stented grafts: effect of intraluminal position on prosthetic graft healing. Surgery. 1996;120:60–70
  6. Yee DC, Williams SK, Salzmann DL, Pond GD, Patula V, Berman SS, et al.  Stent versus endovascular graft healing characteristics in the porcine iliac artery. J Vasc Interv Radiol. 1998;9:609–617
  7. Chalmers RTA, Hoballah JJ, Sharp WJ, Kresowik TF, Corson JD. Effect of an endovascular stent on healing of an end-to-end polytetrafluorethylene-artery anastomosis in a canine model. Br J Surg. 1994;81:1443–1447
  8. Ombrellaro M, Stevens S, Schaeffer D, Freeman MB, Sciarrotta J, Carroll R, et al.  The role of platelet-derived growth factor in intraluminal stented graft healing. J Am Coll Surg. 1997;184:49–57
  9. Ombrellaro M, Stevens S, Sciarrotta J, Schaeffer DO, Freeman MB, Goldman MH. Effect of balloon-expandable and self-expanding stent fixation on endoluminal polytetrafluoroethylene graft healing. Am J Surg. 1997;173:461–466
  10. Shin CK, Rodino W, Kirwin JD, Ramirez JA, Wisselink W, Papierman G, et al.  Histology and electron microscopy of explanted bifurcated endovascular aortic grafts: evidence of early incorporation and healing. J Endovasc Surg. 1999;6:246–250
  11. Marin ML, Veith FJ, Cynamon J, Sanchez LA, Bakal CW, Suggs WD, et al.  Human transluminally placed endovascular stented grafts: Preliminary histopathologic analysis of healing grafts in aortoiliac and femoral artery occlusive disease. J Vasc Surg. 1995;21:595–604
  12. White RA, Donayre CE, deVirgilio C, Weinstein E, Tio F, Kopchok G. Deployment technique and histopathological evaluation of an endoluminal vascular prosthesis used to repair an iliac artery aneurysm. J Endovasc Surg. 1996;3:262–269
  13. McGahan TJ, Berry GA, McGahan SL, White GH, Yu W, May J. Results of autopsy 7 months after successful endoluminal treatment of an infrarenal abdominal aortic aneurysm. J Endovasc Surg. 1995;2:348–355
  14. Laborde JC, Parodi JC, Clem MF, Tio FO, Barone HD, Rivera FJ, et al.  Intraluminal bypass of abdominal aortic aneurysm: feasibility study. Radiology. 1992;184:185–190
  15. Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991;5:491–499
  16. Clowes AW, Kohler T. Graft endothelialization: the role of angiogenic mechanisms. J Vasc Surg. 1991;13:734–736
  17. Golden MA, Hanson SR, Kirkman TR, Schneider PA, Clowes AW. Healing of polytetrafluoroethylene arterial grafts is influenced by graft porosity. J Vasc Surg. 1990;11:838–845
  18. Ombrellaro M, Stevens S, Freeman M, Schaeffer D, Freeman MB, Goldman MH. Effect of intra-arterial environment on endothelialization and basement membrane organization in polytetrafluoroethylene grafts. Am J Surg. 1977;174:29–32
  19. Marois Y, Paris E, Zhang Z, Doillon CJ, King MW, Guidoin RG. Vascugraft microporous polyesterurethane arterial prosthesis as a thoraco-abdominal bypass in dogs. Biomaterials. 1996;13:1289–1300
  20. Contreras MA, Quist WC, Logerfo FW. Effect of porosity on small-diameter vascular graft healing. Microsurgery. 2000;20:15–21
  21. Clowes A, Kiekman T, Reidy M. Mechanisms of arterial graft healing: rapid transmural capillary ingrowth provides a source of intimal endothelium and smooth muscle in porous PTFE prosthesis. Am J Pathol. 1986;123:220–230
  22. Harker LA, Slichter SJ, Sauvage LR. Platelet consumption by arterial prostheses: the effects of endothelialization and pharmacologic inhibition of platelet function. Ann Surg. 1977;186:594–601
  23. Kusaba A, Fischer CR, Matulewski TJ, Matsumoto T. Experimental study of the influence of porosity on development of neointima in Gore-Tex grafts. Am Surg. 1981;47:347–354
  24. Herring M, Baughman S, Glover J, Keseler K, Jesseph J, Campbell J, et al.  Endothelial seeding of Dacron and polytetrafluoroethylene grafts: the cellular events of healing. Surgery. 1985;96:745–754

 Competition of interest: nil.

☆☆ Reprint requests: Michael L. Marin, MD, Henry Kaufmann Professor of Vascular Surgery, Department of Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 (e-mail: michael.marin@mountsinai.org ).

PII: S0741-5214(01)59072-2

doi: 10.1067/mva.2001.113980

Journal of Vascular Surgery
Volume 33, Issue 4 , Pages 733-738 , April 2001