Journal of Vascular Surgery
Volume 34, Issue 4 , Pages 730-738 , October 2001

Pathogenesis of abdominal aortic aneurysms: A multidisciplinary research program supported by the National Heart, Lung, and Blood Institute

Received 9 January 2001 ,Accepted 8 February 2001.

References 

  1. Johnston KW, Rutherford RB, Tilson MD, Shah DM, Hollier L, Stanley JC. Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery. J Vasc Surg. 1991;13:452–458
  2. Hollier LH, Taylor LM, Ochsner J. Recommended indications for operative treatment of abdominal aortic aneurysms. J Vasc Surg. 1992;15:1046–1056
  3. Cole CW, Hill GB, Lindsay J, Mickelson WP, Mills C, Wigle DT. Proceedings of the workshop on the control of abdominal aortic aneurysm. Chronic Dis Can. 1994;15(Suppl):S1–S64
  4. Thompson RW. Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem. Curr Opin Cardiol. 1996;11:504–518
  5. Boyd CD, Tilson MD. The abdominal aortic aneurysm: etiology, pathophysiology and genetics. New York: New York Academy of Science; 1996;
  6. Davies MJ. Aortic aneurysm formation: lessons from human studies and experimental models. Circulation. 1998;98:193–195
  7. Dobrin PB, Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc Surg. 1994;2:484–488
  8. Thompson RW, Parks WC. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci. 1996;800:157–174
  9. Tamarina NA, McMillan WD, Shively VP, Pearce WH. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery. 1997;122:264–271
  10. Shah PK. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation. 1997;96:2115–2117
  11. McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH. Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation. 1997;96:2228–2232
  12. McMillan WD, Pearce WH. Increased plasma levels of metalloproteinase-9 are associated with abdominal aortic aneurysms. J Vasc Surg. 1999;29:122–127
  13. Chiou AC, Chiu B, Oppat WF, Matsumura JS, Chisholm RL, Pearce WH. Transrectal ultrasound assessment of murine aorta and iliac arteries. J Surg Res. 2000;88:193–199
  14. Davis V, Persidskaia R, Baca-Regen L, Itoh Y, Nagase H, Persidsky Y, et al.  Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 1998;18:1625–1633
  15. Thompson RW, Baxter BT. MMP inhibition in abdominal aortic aneurysms: rationale for a prospective randomized clinical trial. Ann N Y Acad Sci. 1999;878:159–178
  16. Petrinec D, Liao S, Holmes DR, Reilly JM, Parks WC, Thompson RW. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg. 1996;23:336–346
  17. Curci JA, Mao D, Bohner DG, Allen BT, Rubin BG, Reilly JM, et al.  Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms. J Vasc Surg. 2000;31:325–342
  18. Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, et al.  Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest. 2000;105:1641–1649
  19. Mao D, Lee JK, VanVickle SJ, Thompson RW. Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. Biochem Biophys Res Commun. 1999;261:904–910
  20. Huffman MD, Curci JA, Moore G, Kerns DB, Starcher BC, Thompson RW. Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery. 2000;128:429–438
  21. Liao S, Curci JA, Kelley B, Sicard GA, Thompson RW. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms as compared to the adjacent inferior mesenteric artery. J Surg Res. 2000;92:85–95
  22. Heinecke JW. Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders. J Lab Clin Med. 1999;133:321–325
  23. Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, et al.  Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods Enzymol. 1999;300:124–144
  24. Heinecke JW. Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall. FASEB J. 1999;13:1113–1120
  25. Parks WC, Pierce RA, Lee KA, Mecham RP. Elastin. Advances in Molecular Cell Biology. 1993;6:133–182
  26. Pierce RA, Kolodziej ME, Parks WC. 1,25-Dihydroxyvitamin D3 represses tropoelastin expression by a posttranscriptional mechanism. J Biol Chem. 1992;267:11593–11599
  27. Swee MH, Parks WC, Pierce RA. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem. 1995;270:14899–14906
  28. Parks WC. Posttranscriptional regulation of lung elastin production. Am J Respir Cell Mol Biol. 1997;17:1–2
  29. Zhang M, Pierce RA, Wachi H, Mecham RP, Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor beta1. Mol Cell Biol. 1999;19:7314–7326
  30. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest. 1998;102:576–583
  31. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, et al.  Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest. 1999;104:1191–1197
  32. McMillan WD, Pearce WH. Inflammation and cytokine signaling in aneurysms. Ann Vasc Surg. 1997;11:540–545
  33. Koch AE, Haines GK, Rizzo RJ, Radosevich JA, Pope RM, Robinson PG, et al.  Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am J Pathol. 1990;137:1199–1213
  34. Gregory AK, Yin NX, Capella J, Xia S, Newman KM, Tilson MD. Features of autoimmunity in the abdominal aortic aneurysm. Arch Surg. 1996;131:85–88
  35. Slachta CA, Jeevanandam V, Goldman B, Lin WL, Platsoucas CD. Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). J Immunol. 2000;165:3469–3483
  36. Tilson MD. Similarities of an autoantigen in aneurysmal disease of the human abdominal aorta to a 36-kDa microfibril-associated bovine aortic glycoprotein. Biochem Biophys Res Commun. 1995;213:40–43
  37. Xia S, Ozsvath K, Hirose H, Tilson MD. Partial amino acid sequence of a novel 40-kDa human aortic protein, with vitronectin-like, fibrinogen-like, and calcium binding domains: aortic aneurysm-associated protein-40 (AAAP-40) [human MAGP-3, proposed]. Biochem Biophys Res Commun. 1996;219:36–39
  38. Hirose H, Ozsvath KJ, Xia S, Tilson MD. Molecular cloning of the complementary DNA for an additional member of the family of aortic aneurysm antigenic proteins. J Vasc Surg. 1997;26:313–318
  39. Hirose H, Takagi M, Miyagawa N, Hashiyada H, Noguchi M, Tada S, et al.  Genetic risk factor for abdominal aortic aneurysm: HLA-DR2(15), a Japanese study. J Vasc Surg. 1998;27:500–503
  40. Borromeo JR, Koshy N, Park WM, Xia S, Hardy K, Tilson MD. Regional distribution in the mouse of proteins homologous to artery-specific antigenic proteins (ASAPs). J Surg Res. 1999;85:217–224
  41. Chew DK, Knoetgen , Xia S, Gaetz HP, Tilson MD. Regional distribution in human of a novel aortic collagen-associated microfibrillar protein. Exp Mol Pathol. 1999;66:59–65
  42. Vorp DA, Trachtenberg JD, Webster MW. Arterial hemodynamics and wall mechanics. Semin Vasc Surg. 1998;11:169–180
  43. Masuda H, Zhuang YJ, Singh TM, Kawamura K, Murakami M, Zarins CK, et al.  Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol. 1999;19:2298–2307
  44. Tropea BI, Schwarzacher SP, Chang A, Asvar C, Huie P, Sibley RK, et al.  Reduction of aortic wall motion inhibits hypertension-mediated experimental atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20:2127–2133
  45. Abbruzzese TA, Guzman RJ, Martin RL, Yee C, Zarins CK, Dalman RL. Matrix metalloproteinase inhibition limits arterial enlargements in a rodent arteriovenous fistula model. Surgery. 1998;124:328–334
  46. Karwowski JK, Markezich A, Whitson J, Abbruzzese TA, Zarins CK, Dalman RL. Dose-dependent limitation of arterial enlargement by the matrix metalloproteinase inhibitor RS-113,456. J Surg Res. 1999;87:122–129
  47. Vorp DA, Raghavan ML, Webster MW. Mechanical wall stress in abdominal aortic aneurysm: influence of diameter and asymmetry. J Vasc Surg. 1998;27:632–639
  48. Fillinger MF. New imaging techniques in endovascular surgery. Surg Clin North Am. 1999;79:451–475
  49. Kyriacou SK, Humphrey JD. Influence of size, shape and properties on the mechanics of axisymmetric saccular aneurysms. J Biomech. 1996;29:1015–1022
  50. Shah AD, Humphrey JD. Finite strain elastodynamics of intracranial saccular aneurysms. J Biomech. 1999;32:593–599
  51. Shah AD, Naff N, Humphrey JD, Rigamonti D. Mechanical behavior of a vein pouch saccular aneurysm model. Neurol Res. 1999;21:569–573
  52. Ryan JM, Humphrey JD. Finite element based predictions of preferred material symmetries in saccular aneurysms. Ann Biomed Eng. 1999;27:641–647
  53. Kuivaniemi H, Marshall A, Ganguly A, Chu ML, Abbott WM, Tromp G. Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms. Eur J Hum Genet. 1998;6:642–646
  54. Wang X, Tromp G, Cole CW, Verloes A, Sakalihasan N, Yoon S, et al.  Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol. 1999;18:121–124
  55. Yoon S, Tromp G, Vongpunsawad S, Ronkainen A, Juvonen T, Kuivaniemi H. Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun. 1999;265:563–568

 Competition of interest: Dr Fillinger has received grant/research support in the past (2 in the last year) from Medical Medic Systems; Dr Sukhova is a coinvestigator in National Institutes of Health/National Health, Lung, and Blood Institute (HL60942, primary investigator is Dr Guo-Ping Shi) “Roles of cystein proteases in atherosclerosis.”

☆☆ The views expressed herein are those of the authors and do not necessarily reflect the views of the National Institutes of Health and the National Heart, Lung, and Blood Institute.

 Reprint requests: Momtaz Wassef, PhD, Atherosclerosis Scientific Research Group Leader, Vascular Biology Research Program, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Two Rockledge Centre, Room 10196, 6701 Rockledge Drive, Bethesda, MD 20892-7956 (e-mail: wassefm@nih.gov ).

★★ J Vasc Surg 2001;34:730-8.

PII: S0741-5214(01)25403-2

doi: 10.1067/mva.2001.116966

Journal of Vascular Surgery
Volume 34, Issue 4 , Pages 730-738 , October 2001