Journal of Vascular Surgery
Volume 34, Issue 4 , Pages 724-729 , October 2001

Saratin, an inhibitor of von Willebrand factor–dependent platelet adhesion, decreases platelet aggregation and intimal hyperplasia in a rat carotid endarterectomy model

Presented at the Twenty-fourth Annual Meeting of the Southern Association for Vascular Surgery, Tucson, Ariz, Jan 19-22, 2000.

Received 31 January 2001 ,Accepted 12 February 2001.

  • Image Result

    Number of platelets adherent to exposed subendothelial surface 3 hours after carotid endarterectomy, comparing saratin-treated group (n = 7) and control group (n = 10). Data are means ± SE. Platelets

    Number of platelets adherent to exposed subendothelial surface 3 hours after carotid endarterectomy, comparing saratin-treated group (n = 7) and control group (n = 10). Data are means ± SE. Platelets were counted with scanning electron microscope. Saratin group received 5 μL of saratin solution applied topically to exposed subendothelial surface. Star indicates P value of .05.

  • Image Result
    Number of platelets adherent to exposed subendothelial surface 24 hours after carotid endarterectomy comparing saratin-treated group (n = 9) and control group (n = 10). Data are means ± SE. Platelets

    Number of platelets adherent to exposed subendothelial surface 24 hours after carotid endarterectomy comparing saratin-treated group (n = 9) and control group (n = 10). Data are means ± SE. Platelets were counted with scanning electron microscope. Saratin group received 5 μL of saratin solution applied topically to exposed subendothelial surface. Star indicates P value of .01.

  • Image Result
    Electron micrograph (2000×) of endarterectomized rat carotid artery 3 hours after carotid endarterectomy. A, Control surface. B, Surface receiving topical saratin (5 μL). Control surface shows abundan

    Electron micrograph (2000×) of endarterectomized rat carotid artery 3 hours after carotid endarterectomy. A, Control surface. B, Surface receiving topical saratin (5 μL). Control surface shows abundant cellular elements including fibrin strands, red blood cells, and platelets. Saratin-treated surface shows marked decrease in cellular elements.

  • Image Result
    Electron micrograph (2000×) of endarterectomized rat carotid artery 24 hours after carotid endarterectomy. A, Control surface. B, Surface receiving topical saratin (5 μL). Control surface shows numero

    Electron micrograph (2000×) of endarterectomized rat carotid artery 24 hours after carotid endarterectomy. A, Control surface. B, Surface receiving topical saratin (5 μL). Control surface shows numerous red blood cells and platelets. Saratin- treated surface shows marked decrease in platelet adhesion.

  • Image Result
    Percent luminal stenosis resulting from intimal hyperplasia 2 weeks after carotid endarterectomy. Saratin-treated group (n = 15) and control group (n = 10) are shown. Saratin group received 5 μL of sa

    Percent luminal stenosis resulting from intimal hyperplasia 2 weeks after carotid endarterectomy. Saratin-treated group (n = 15) and control group (n = 10) are shown. Saratin group received 5 μL of saratin applied topically to exposed subendothelial surface. Star indicates P value of .004.

☆ Competition of interest: nil.

☆☆ Funded in part by Merck KGaA, Hornick Endowment Fund University of Arkansas for Medical Sciences.

★ Reprint requests: Mohammed M. Moursi, MD, Department of Surgery, Division of Vascular Surgery, University of Arkansas for Medical Sciences, Slot 520, 4301 West Markham St, Little Rock, AR 72205 (e-mail: MoursiMohammedM@exchange.uams.edu ).

PII: S0741-5214(01)24605-9

doi: 10.1067/mva.2001.116801

Journal of Vascular Surgery
Volume 34, Issue 4 , Pages 724-729 , October 2001

Article Tools

* Image Usage & Resolution