Journal of Vascular Surgery
Volume 17, Issue 2 , Pages 371-381 , February 1993

Adventitial elastolysis is a primary event in aneurysm formation

Presented at the Fortieth Scientific Meeting of the International Society for Cardiovascular Surgery, North American Chapter, Chicago, Ill., June 9-10, 1992.

Received 12 June 1992 ,Accepted 28 September 1992.

References 

  1. Sumner DS, Hokanson DE, Strandness DE. Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms. Surg Gynecol Obstet. 1970;130:459–466
  2. Busuttil RW, Rinderbriecht H, Flecher A, Carnack C. Elastase activity: the role of elastase in aortic aneurysm formation. J Surg Res. 1982;32:214–217
  3. Tilson MD. Histochemistry of aortic elastin in patients with nonspecific AAA disease. Arch Surg. 1988;123:503–505
  4. Powell JT. Dilatation through loss of elastin. In:  Greenhalgh RM,  Mannick JA editor. The cause and management of aneurysms. Philadelphia: WB Saunders; 1990;p. 89–96
  5. Halsted WS. Circumscribed dilation of an artery immediately distal to a partially occluding band. J Exp Med. 1916;24:271–286
  6. Holman E. The obscure physiology and poststenotic dilation: its relation to the development of aneurysms. J Thorac Surg. 1954;28:109–133
  7. Zatina MA, Zarins CK, Gewertz BL, Glagov S. Role of medial lamellar architecture in the pathogenesis of aortic aneurysms. J Vasc Surg. 1984;1:442–448
  8. Campa JS, Greenhalgh RM, Powell JT. Elastin degradation in abdominal aortic aneurysms. Atheroscler Thromb. 1987;65:13–21
  9. Dubick MA, Hunter GC, Perez-Lizano E, Mar G, Geokas MC. Assessment of the role of pancreatic proteases in human abdominal aortic aneurysms and occlusive disease. Clin Chim Acta. 1988;177:1–10
  10. Cannon DJ, Read R. Blood elastolytic activity in patients with aortic aneurysm. Ann Thorac Surg. 1982;34:10–15
  11. Cohen JR, Mandell C, Margolis I, Chang J, Wise L. Altered aortic protease and antiprotease activity in patients with ruptured abdominal aortic aneurysms. Surg Gynecol Obstet. 1987;164:355–358
  12. Rutherford RB. Arterial aneurysm: etiologic considerations. In:  Rutherford RB editors. Vascular surgery. Philadelphia: WB Saunders; 1989;p. 238–245
  13. Burton AC. Relation of structure to function of the tissues of the wall of blood vessels. Physiol Rev. 1954;334:619–642
  14. Apter JT, Rabinowitz M, Cummings DH. Correlation of viscoelastic properties of large arteries with microscopic structure. Circ Res. 1966;19:104–120
  15. Thornell LE, Norrgard O, Eriksson A, Vanderwee M, Angqvist KA. Abdominal aortic aneurysms: distribution of elastin, collagen I and III, and intermediate filament proteins desmin and vimentin—a comparison of familial and nonfamilial aneurysms. Heart Vessels. 1986;2:172–183
  16. Rizzo RJ, McCarthy WJ, Dixit SN, et al.  Collagen types and matrix protein content in human abdominal aortic aneurysms. J Vasc Surg. 1989;10:365–373
  17. Anidjar S, Salzmann JL, Gentric D, Lagneau P, Camilleri JP, Michel JB. Elastase-induced experimental aneurysms in rats. Circulation. 1990;82:973–981
  18. Dobrin PB, Baker WH, Gley WC. Elastolytic and collagenolytic studies of arteries: implications for the mechanical properties of aneurysms. Arch Surg. 1984;119:405–409
  19. Tilson DM, Elefteriades J, Brophy CM. Tensile strength and collagen in abdominal aortic aneurysm disease. In:  Green-halgh RM,  Mannick JA,  Powell JT editor. The cause and management of aneurysms. London: WB Saunders; 1990;p. 97–104
  20. Haas KS, Phillips SJ, Comerota AJ, White JV. The architecture of adventitial elastin in the canine infrarenal aorta. Anat Rec. 1991;230:86–96
  21. Butcher HR. The elastic properties of human aortic intima, media and adventitia: the initial effect of thromboendarterectomy. Ann Surg. 1960;151:480–489
  22. Summer DS, Hokanson DE, Strandness DE. Arterial walls before and after endarterectomy: stress-strain characteristics and collagen-elastin content. Arch Surg. 1969;99:606–611
  23. Dobrin PB, Schwarcz TH, Baker WH. Mechanisms of arterial and aneurysmal tortuosity. Surgery. 1988;104:568–571
  24. McGee GS, Baxter BT, Shively VP, et al.  Aneurysm or occlusive disease: factors determining the clinical course of atherosclerosis of the infrarenal aorta. Surgery. 1991;110:370–376

☆ Reprint requests: John V. White, MD, Temple University Hospital, 3401 N. Broad St., Philadelphia, PA 19140.

PII: 0741-5214(93)90422-I

doi: 10.1067/mva.1993.43023

Journal of Vascular Surgery
Volume 17, Issue 2 , Pages 371-381 , February 1993

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